主页 > 医药科学 >
【medical-news】部分直肠癌患者新辅助化疗后可避
Non-operative treatment after neoadjuvant chemoradiotherapy for rectal cancer.
O'Neill BD, Brown G, Heald RJ, Cunningham D, Tait DM.
The past decade has seen pronounced changes in the treatment of locally advanced rectal cancer. Historically, the standard of care involved surgery followed by adjuvant radiotherapy or chemoradiotherapy. More recently, the emergence of neo-adjuvant chemoradiotherapy has fundamentally changed the management of patients with locally advanced disease. In clinical trials, pathological complete responses of up to 25% have raised the question as to whether surgery can be avoided in a select cohort of patients. A trial of omission of surgery for selected patients with complete response after preoperative chemoradiotherapy has shown favourable long-term results. In this article, we outline emerging factors for achieving pathological complete response, non-operative strategies to date, methods for prediction of response to chemoradiotherapy, and future directions with the addition of MRI as a radiological guide to complete response. 800帖
纪念于此
screen.width-333)this.width=screen.width-333" width=210 height=353 title="Click to view full 1.JPG (210 X 353)" border=0 align=absmiddle> 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Lancet Oncol. 2007 Jul;8(7):625-33.
柳叶刀肿瘤版 2007年7月；8(7):625-33.
Non-operative treatment after neoadjuvant chemoradiotherapy for rectal cancer.
部分直肠癌患者新辅助化疗后可避免手术
O'Neill BD, Brown G, Heald RJ, Cunningham D, Tait DM.
The past decade has seen pronounced changes in the treatment of locally advanced rectal cancer.
限局型浸润型结肠癌的治疗在过去的十年里已经有了显著的变化。
Historically, the standard of care involved surgery followed by adjuvant radiotherapy or chemoradiotherapy.
过去，标准的治疗包括手术加辅助放疗或者是放化疗。
More recently, the emergence of neo-adjuvant chemoradiotherapy has fundamentally changed the management of patients with locally advanced disease.
最近，新辅助放化疗的出现已经根本改变了限局型浸润型结肠癌患者的治疗方式。
In clinical trials, pathological complete responses of up to 25% have raised the question as to whether surgery can be avoided in a select cohort of patients.
在许多临床实验中，病理证实近25%的新辅助化疗治疗完全有效，使得人们不禁要问：“部分选择的病人是否可以不需要手术治疗？”
A trial of omission of surgery for selected patients with complete response after preoperative chemoradiotherapy has shown favourable long-term results. In this article, we outline emerging factors for achieving pathological complete response, non-operative strategies to date, methods for prediction of response to chemoradiotherapy, and future directions with the addition of MRI as a radiological guide to complete response.
一项临床试验表明经过选择的病人经过术前放化疗而不施行手术的长期疗效令人满意。在这篇文章中，我们总结出达到病理治愈的初始因素、迄今为止的非手术策略、预测放化疗反应的方法、增加磁共振剑检查作为评估治愈的影像学指南的发展方向。
编译：：
柳叶刀肿瘤版 2007年7月；8(7):625-33.
部分直肠癌患者新辅助化疗后可避免手术
O'Neill BD, Brown G, Heald RJ, Cunningham D, Tait DM.
限局型浸润型结肠癌的治疗在过去的十年里已经有了显著的变化。
过去，标准的治疗包括手术加辅助放疗或者是放化疗。
最近，新辅助放化疗的出现已经根本改变了限局型浸润型结肠癌患者的治疗方式。
在许多临床实验中，病理证实近25%的新辅助化疗治疗完全有效，使得人们不禁要问：“部分选择的病人是否可以不需要手术治疗？”
一项临床试验表明经过选择的病人经过术前放化疗而不施行手术的长期疗效令人满意。在这篇文章中，我们总结出达到病理治愈的初始因素、迄今为止的非手术策略、预测放化疗反应的方法、增加磁共振剑检查作为评估治愈的影像学指南的发展方向。 [标签:content1][标签:content2]
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-02-16 05:14
医学,生命科学网