主页 > 医药科学 >
【medical-news】白血病治疗的又一靶点--- stat5
Deakin University discovery could lead to new leukaemia treatments
Deakin University scientists have identified a protein that could hold the key to new leukaemia treatments.
The protein--Stat5--was investigated at a laboratory at Deakin's Melbourne Campus at Burwood, as part of a multicentre international collaboration.
Leukaemia is a cancer caused by a proliferation of white blood cells. To understand and help prevent the disease, the Deakin researchers are looking for the responsible genes.
Head of the Deakin team, Associate Professor Alister Ward, said the discovery of how the protein acts provides a breakthrough in understanding the onset of leukaemia.
"We have found that Stat5 is responsible for making white blood cells overgrow in a particular disease setting that often precedes leukaemia," Associate Professor Ward explained.
"On top of this, we have also found that Stat5, when activated, is sufficient on its own to cause white blood cells to overgrow inside a whole organism.
"Together, these findings identify Stat5 as a major player in the process of leukaemia progression and is therefore a worthwhile target for intervention."
Associate Professor Ward said the next step in this research was to utilise the model systems established to develop new therapeutics. 本人已经认领此文. 如在48小时内未能提交译文, 其他战友可自由认领. Deakin University discovery could lead to new leukaemia treatments
迪肯大学的发现有助于开发新的白血病治疗方法
Deakin University scientists have identified a protein that could hold the key to new leukaemia treatments.
迪肯大学研究人员鉴别了一种蛋白质， 可能有助于开发白血病新疗法。
The protein--Stat5--was investigated at a laboratory at Deakin's Melbourne Campus at Burwood, as part of a multicentre international collaboration.
作为国际多中心合作的一部分，迪肯大学墨尔本学部的研究人员调查了一种名为Stat5的蛋白质。
Leukaemia is a cancer caused by a proliferation of white blood cells. To understand and help prevent the disease, the Deakin researchers are looking for the responsible genes.
白血病是一种由于白细胞增生导致的癌症。迪肯大学的研究人员致力于寻找相关基因，从而可以了解并预防此病。
Head of the Deakin team, Associate Professor Alister Ward, said the discovery of how the protein acts provides a breakthrough in understanding the onset of leukaemia.
研究小组带头人，Alister Ward副教授称，他们发现了Stat5如何作用，这对于理解白血病的发病是一大突破。
"We have found that Stat5 is responsible for making white blood cells overgrow in a particular disease setting that often precedes leukaemia," Associate Professor Ward explained.
"On top of this, we have also found that Stat5, when activated, is sufficient on its own to cause white blood cells to overgrow inside a whole organism.
"Together, these findings identify Stat5 as a major player in the process of leukaemia progression and is therefore a worthwhile target for intervention."
Ward说：“我们发现Stat5在某种白血病前期病变中能促进白细胞过度增生。最重要的是，我们还发现Stat5活化本身就足以导致整个机体内白细胞过度增生。这些说明，Stat5在白血病进展中起重要作用，所以也是介入治疗的新靶点。
Associate Professor Ward said the next step in this research was to utilise the model systems established to develop new therapeutics.
Ward说这个研究下一步将应用动物模型开发新疗法。 编译
白血病治疗的又一靶点--- stat5
白血病是一种由于白细胞异常增生导致的癌症。
澳大利亚迪肯大学的研究人员近日发现，一种名为Stat5的蛋白质在某种白血病前期病变中能促进白细胞过度增生，而且Stat5活化本身就足以导致整个机体内白细胞过度增生。这说明Stat5在白血病发病及进展中起重要作用，所以也可以作为介入治疗的新靶点。
这一发现对于理解白血病的发病是一大突破，也有助于开发新的白血病治疗方法
研究人员将进一步将应用动物模型开发新疗法。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2010-10-29 05:11
医学,生命科学网