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【medical-news】纳米技术帮助改进影像诊断早期癌
MONDAY, Aug. 18 (HealthDay News) -- Nanotechnology may offer doctors a noninvasive way to detect early stages of cancer and also help monitor treatment, a new report says.
Researchers at Stanford University School of Medicine recently demonstrated the new approach using "smart" targeted carbon nanotubes to zero in on cancer cells in living mice, followed by laser scans of the animals in which the nanotubes absorbed the laser energy and released ultrasound waves to highlight the locations of the tumor cells.
"This imaging modality allows us to see things we've never been able to see before," study author Adam de la Zerda, a doctoral student in Stanford electrical engineering, said in a news release issued by the university.
The findings were expected to be published online Aug. 17 in Nature Nanotechnology.
The technology takes advantage of the "photoacoustic effect," a physical phenomenon in which light hits an object and is converted into sound. Shining light on an object heats it up, de la Zerda said.
"Think of a black car parked in the sun," he said. The car warms up, and the metal expands. Later, the cooling, shrinking metal makes little "tink" sounds.
"We shine light on a nanotube and listen to the ultrasound waves coming out of it," de la Zerda said.
The technique is faster and costs less than an MRI scan and requires no ionizing radiation like a PET-CT scan, the researchers said. Its ability to look 2 inches deep into the body would make it helpful for looking at tissues in the breast or prostate gland.
The method is sensitive enough to detect minute, early tumors that normally can't be seen, the researchers said. Also, the scanners could also be adapted to endoscopes, enabling views of internal organs.
Coatings on the nanotubes could also be altered so doctors could receive diagnostic information about a tumor, de la Zerda said. For instance, molecules put on nanotubes could tell a doctor which anti-cancer drugs would work on a breast tumor.
"We will be able to ask a tumor: Are you responding to chemotherapy or not?" de la Zerda said. "This should give us early information long before the tumor shrinks or grows."
A companion study in mice, published in Nature Nanotechnology in April, found the carbon nanotubes appear to be safe to inject, although further testing is needed before testing can begin in humans. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 MONDAY, Aug. 18 (HealthDay News) -- Nanotechnology may offer doctors a noninvasive way to detect early stages of cancer and also help monitor treatment, a new report says.
8月18日周一（HealthDay News）一份新的报告称：纳米技术可为医生提供针对癌症早期的无创检测方法，这一方法也有利于监测治疗效果。
Researchers at Stanford University School of Medicine recently demonstrated the new approach using "smart" targeted carbon nanotubes to zero in on cancer cells in living mice, followed by laser scans of the animals in which the nanotubes absorbed the laser energy and released ultrasound waves to highlight the locations of the tumor cells.
斯坦福大学医学院的研究人员最近证明：在活体小鼠使用“智能”的对肿瘤细胞针对性的碳纳米管的新方法，其次是用激光扫描的动物身体中碳纳米管的释放出的吸收激光能量及超声波，可以准确定位出肿瘤细胞。
"This imaging modality allows us to see things we've never been able to see before," study author Adam de la Zerda, a doctoral student in Stanford electrical engineering, said in a news release issued by the university.
“这种成像方式，使我们能够看到我们之前从来没有能够看到的东细 ”研究作者Adam de la Zerda ，斯坦福大学电机工程博士生，在大学新闻发布说。
The findings were expected to be published online Aug. 17 in Nature Nanotechnology.
研究结果预计将在8月17日网上的Nature Nanotechnology公布。
The technology takes advantage of the "photoacoustic effect," a physical phenomenon in which light hits an object and is converted into sound. Shining light on an object heats it up, de la Zerda said.
该技术利用物理现象上的“光声效应”，就是光波碰击一个物体，然后被转换成声音。发亮的光照会使物体热起来，de la Zerda说。
"Think of a black car parked in the sun," he said. The car warms up, and the metal expands. Later, the cooling, shrinking metal makes little "tink" sounds.
“设想：一两黑色的汽车停在阳光底下， ”他说。汽车会热起来，然后金属会膨胀，后来，再冷却，萎缩，金属会发出小“ tink ”的声音。
"We shine light on a nanotube and listen to the ultrasound waves coming out of it," de la Zerda said.
“我们把光照对准一个碳纳米管，并听取他们发出的超声波，” de la Zerda说。
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作者:admin@医学,生命科学 2011-01-14 05:14
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