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【medical-news】肠促胰岛素类似物Byetta：诱发急性
Diabetes Drug Byetta: Pancreas Risk?
FDA Notes 30 Cases of Acute Pancreatitis in Patients Taking Byetta; Cause Unclear
Oct. 16, 2007 -- The FDA today announced that is has gotten 30 reports of a potentially deadly pancreas problem in patients taking the type 2 diabetes drug Byetta.
Those patients developed acute pancreatitis, which is inflammation of the pancreas. Twenty-one of the patients were hospitalized. None died.
The FDA has this advice for patients taking Byetta: Seek medical care promptly if you experience unexplained severe abdominal pain with or without nausea and vomiting.
Doctors should discontinue Byetta in patients suspected to have acute pancreatitis and not restart the patients on Byetta unless they find another cause for the patients' acute pancreatitis, according to the FDA.
It's not clear if Byetta caused the 30 reported cases of acute pancreatitis.
Most of those patients -- 27 out of 30 -- had other risk factors for acute pancreatitis, including gallstones, alcohol use, and severe hypertriglyceridemia (extremely high levels of triglycerides)
Twenty-two of the patients improved after discontinuing Byetta. Symptoms of acute pancreatitis returned when three of the patients started using Byetta again, according to the FDA.
The FDA says that Byetta's maker, Amylin Pharmaceuticals, has agreed to include information on acute pancreatitis in the "precautions" section of the drug's label.
A spokeswoman for Amylin Pharmaceuticals, which makes Byetta, was not immediately available for comment.
http://diabetes.webmd.com/news/20071016/diabetes-drug-byetta-pancreas-risk Diabetes Drug Byetta: Pancreas Risk?
FDA Notes 30 Cases of Acute Pancreatitis in Patients Taking Byetta; Cause Unclear
Byetta：胰腺的危险？
美国食品药品管理局FDA提出30例用Byetta的患者出现胰腺炎；原因还不清楚
Oct. 16, 2007 -- The FDA today announced that is has gotten 30 reports of a potentially deadly pancreas problem in patients taking the type 2 diabetes drug Byetta.
2007，10，16---美国食品药品管理局FDA通告用Byetta的30例2型糖尿病人出现潜在的致命的胰腺问题
Those patients developed acute pancreatitis, which is inflammation of the pancreas. Twenty-one of the patients were hospitalized. None died.
患者发生急性胰腺炎，也就是胰腺的炎症，21人住院治疗，未见死亡病例。
The FDA has this advice for patients taking Byetta: Seek medical care promptly if you experience unexplained severe abdominal pain with or without nausea and vomiting.
FDA劝告用Byetta的患者，如果出现不清楚的腹痛，或者有也可能没有恶心，呕吐，要立刻就医
Doctors should discontinue Byetta in patients suspected to have acute pancreatitis and not restart the patients on Byetta unless they find another cause for the patients' acute pancreatitis, according to the FDA.
根据 FDA的意见，怀疑有急性胰腺炎的患者，医生必须停用Byetta，也不要重新开始，除非他们发现引起急性胰腺炎的其他原因
It's not clear if Byetta caused the 30 reported cases of acute pancreatitis.
是否30例急性胰腺炎是Byetta引起，还不是很清楚。
Most of those patients -- 27 out of 30 -- had other risk factors for acute pancreatitis, including gallstones, alcohol use, and severe hypertriglyceridemia (extremely high levels of triglycerides)
绝大多数患者，30个中的27个，有其他急性胰腺炎的危险因素，包括胆结石，喝酒严重的高甘油三脂血症（甘油三脂水平极高）
Twenty-two of the patients improved after discontinuing Byetta. Symptoms of acute pancreatitis returned when three of the patients started using Byetta again, according to the FDA.
据FDA称，21个患者停用Byetta后病情改善，其中三人当其再用Byetta时，急性胰腺炎的症状又再次出现。
The FDA says that Byetta's maker, Amylin Pharmaceuticals, has agreed to include information on acute pancreatitis in the "precautions" section of the drug's label.
FDA称Byetta生产商，阿姆林Amylin药业公司，同意在药物标签的“敬告”处，表明急性胰腺炎的信号
A spokeswoman for Amylin Pharmaceuticals, which makes Byetta, was not immediately available for comment.
生产 Byetta的阿姆林Amylin药业公司的一位女发言人，还不能立刻采用这一意见
编译
Byetta：胰腺的危险？
2007，10，16---美国食品药品管理局FDA通告用Byetta的30例2型糖尿病人出现潜在的致命的胰腺问题
用Byetta患者发生急性胰腺炎， 21人住院治疗，未见死亡病例。
FDA劝告用Byetta的患者，如果出现不清楚的腹痛，或者有，也可能没有恶心，呕吐，要立刻就医
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作者:admin@医学,生命科学 2011-05-27 05:11
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