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【文摘发布】6-11真菌在慢性鼻鼻窦炎病因学中的
The role of fungi in the etiology of chronic rhinosinusitis:A prospective study
Auris Nasus Larynx 34 (2007) 185–189
Maky Hafidh a,*, Michael Harney , Robin Kane , Martin Donnelly , Robert Landers c, David Smyth a
Objectives: Allergic fungal sinusitis (AFS) may represent an endpoint in a spectrum of sinonasal disease. Patients fulfilling criteria for a diagnosis of AFS have a poor prognosis often requiring multiple surgeries. The detection of ‘allergic mucin’ with mucus containing clusters of eosinophils and the detection of fungi by histological examination or culture is key criteria necessary for diagnosis. This study was performed to assess the strength of the association of the presence of fungi with the presence of eosinophils in a group of patients with chronic rhinosinusitis and controls.
Methods: Thirty patients with a clinical diagnosis of chronic rhinosinusitis and 10 individuals as control group were selected for the study. Total serum IgE level testing, nasal mucus cytology and fungal culture were performed in all subjects.
Results: Fungal spores were present in the nasal mucus in 14 patients with rhinosinusitis, and in 7 controls. The detection of eosinophils on cytology correlated significantly both with a clinical diagnosis of chronic rhinosinusitis (95% confidence intervals (CI) 0.34–0.81) and with the presence of fungal elements on cytology ( p = 0.02). The average serum IgE level was higher in patients with fungal spores ( p = 0.039).
Conclusion: In certain susceptible individuals inhaled fungi may provoke an eosinophilic response. This response varies from simple eosinophilic inflammation to classic allergic fungal sinusitis. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 回顾性分析真菌在慢性鼻鼻窦炎病因学中的作用
The role of fungi in the etiology of chronic rhinosinusitis:A prospective study
Auris Nasus Larynx 34 (2007) 185–189
Maky Hafidh a,*, Michael Harney , Robin Kane , Martin Donnelly , Robert Landers c, David Smyth a
Objectives: Allergic fungal sinusitis (AFS) may represent an endpoint in a spectrum of sinonasal disease. Patients fulfilling criteria for a diagnosis of AFS have a poor prognosis often requiring multiple surgeries. The detection of ‘allergic mucin’ with mucus containing clusters of eosinophils and the detection of fungi by histological examination or culture is key criteria necessary for diagnosis. This study was performed to assess the strength of the association of the presence of fungi with the presence of eosinophils in a group of patients with chronic rhinosinusitis and controls.
目的：变态反应性真菌性鼻窦炎可能是鼻腔鼻窦疾病细菌谱的一个终末点。满足变态反应性真菌性鼻窦炎诊断标准的患者常常预后不良，并且经常需要进行复杂的外科手术治疗。变态反应性粘蛋白的检出、粘膜内含有嗜酸性粒细胞簇并且在组织学检查和组织培养中检出真菌是诊断所必须的关键标准。这项研究的实施是为了评价慢性鼻、鼻窦炎患者组和对照组的真菌存在量与嗜酸性粒细胞存在量之间的浓度相关性。 The role of fungi in the etiology of chronic rhinosinusitis:A prospective 学生深感受益,并对斑竹的英文功底深表钦佩 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-04-27 05:11
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