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【medical-news】吸入速尿能减轻COPD呼吸困难
Furosemide Inhalation Can Alleviate Dyspnea in COPD
NEW YORK (Reuters Health) Jul 18 - Inhalation of furosemide relieves exertional dyspnea in some patients with chronic obstructive pulmonary disease (COPD), according to a report by researcher in Canada.
Previous studies have shown that inhalation of nebulized furosemide alleviates the sensation of dyspnea provoked by different respiratory stimuli applied experimentally in healthy human subjects, the authors explain in the July issue of Thorax.
Dr. Denis E. O'Donnell and colleagues from Queen's University in Kingston, Ontario, compared the effects of inhaled furosemide or placebo on dyspnea intensity, airway function, ventilation, and other measures during high-intensity constant-load exercise in 20 patients with COPD.
Exercise endurance time increased by an average of 21% (1.65 minutes) after treatment with furosemide compared with placebo, the authors report, and dyspnea intensity during exercise decreased by 0.9 Borg units with furosemide compared with placebo.
At the symptom-limited end point of exercise, furosemide inhalation was associated with small but significant increases in peak oxygen uptake, CO2 production, minute ventilation, and mean expiratory tidal flow.
At baseline, those who responded to furosemide had significantly less severe expiratory airflow limitation and hyperinflation than did nonresponders, the investigators report.
"Nebulized furosemide was associated with consistent and potentially clinically important improvements in dyspnea intensity and exercise endurance in patients with advanced COPD," the researchers conclude. "These acute improvements in exertional dyspnea are multifactorial and could not be explained by alterations in ventilatory demand or pulmonary gas exchange."
"This study therefore supports the rationale for future assessment of inhaled furosemide as a therapeutic intervention for patients with COPD with incapacitating dyspnea," the authors add. Furosemide Inhalation Can Alleviate Dyspnea in COPD
吸入速尿能减轻COPD呼吸困难
NEW YORK (Reuters Health) Jul 18 - Inhalation of furosemide relieves exertional dyspnea in some patients with chronic obstructive pulmonary disease (COPD), according to a report by researcher in Canada.
纽约（路透社 健康）7月18日——一项加拿大研究发现，吸入速尿可缓解部分COPD患者的劳力性呼吸困难。
Previous studies have shown that inhalation of nebulized furosemide alleviates the sensation of dyspnea provoked by different respiratory stimuli applied experimentally in healthy human subjects, the authors explain in the July issue of Thorax.
在7月刊的胸科杂志上，作者解释说，先前的研究发现雾化吸入速尿在健康人能通过不同途径刺激呼吸，缓解呼吸困难。
Dr. Denis E. O'Donnell and colleagues from Queen's University in Kingston, Ontario, compared the effects of inhaled furosemide or placebo on dyspnea intensity, airway function, ventilation, and other measures during high-intensity constant-load exercise in 20 patients with COPD.
Exercise endurance time increased by an average of 21% (1.65 minutes) after treatment with furosemide compared with placebo, the authors report, and dyspnea intensity during exercise decreased by 0.9 Borg units with furosemide compared with placebo.
安大略省金斯顿市昆士兰大学的Denis E. O'Donnell博士和其同事比较了20名COPD患者在高强度连续负荷试验中吸入速尿和安慰剂的作用，评价指标包括呼吸困难程度，气道功能，通气量和其他指标。与安慰剂组相比，吸入速尿组运动耐受时间平均增加21%（1.65分钟），呼吸困难程度降低0.9Borg单位。
At the symptom-limited end point of exercise, furosemide inhalation was associated with small but significant increases in peak oxygen uptake, CO2 production, minute ventilation, and mean expiratory tidal flow.
吸入速尿，可使在运动耐量极限点，摄氧峰值，二氧化碳产生，每分钟通气量和平均呼气峰速产生较小但有统计学意义的提高。
At baseline, those who responded to furosemide had significantly less severe expiratory airflow limitation and hyperinflation than did nonresponders, the investigators report.
研究人员报道，基础水平时，对速尿有反应者与无反应者相比，严重的呼气流量受限和过度充气显著下降。
"Nebulized furosemide was associated with consistent and potentially clinically important improvements in dyspnea intensity and exercise endurance in patients with advanced COPD," the researchers conclude. "These acute improvements in exertional dyspnea are multifactorial and could not be explained by alterations in ventilatory demand or pulmonary gas exchange."
"This study therefore supports the rationale for future assessment of inhaled furosemide as a therapeutic intervention for patients with COPD with incapacitating dyspnea," the authors add.
研究人员认为，雾化吸入速尿在进展期的COPD患者，能持续显著改善呼吸困难和运动耐量。这种劳力性呼吸困难的短期改善是多因素作用的结果，不能通过通气需求和肺气体交换的改变来解释。作者补充说，该研究为将来采用速尿吸入作为治疗呼吸困难的手段提供了理论依据。 吸入速尿能减轻COPD呼吸困难
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作者:admin@医学,生命科学 2011-04-06 17:14
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