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【商业翻译】Vitamin A Metabolite May Play Role in Obesi
1.保证质量。
2.本星期六（6.2 本人认领此文. 如在48小时内未能提交译文, 其他战友自由认领. 译文508字.
Vitamin A Metabolite May Play Role in Obesity
维生素A代谢产物可能与肥胖有关
Retinaldehyde (Rald), a metabolite of vitamin A, increases the generation of adipose tissue and decreases insulin sensitivity, 318字。
哈佛大学研究结果表明，维生素A代谢产物视黄醛可以减少脂肪组织生成，提高胰岛素敏感性。（Nature Medicine，5月27日）。
视黄醛是维生素A的天然衍生物，在控制基因表达方面起到重要且相当独特的作用，它也因此成为控制能量平衡、肥胖及糖尿病等反应的关键影响因子。
视黄醛与视黄醇结合蛋白结合，抑制脂肪形成，同时抑制过氧化物酶体增殖物激活受体γ及视黄醇类X受体（RXR）的反应。缺乏视黄醛降解酶的小鼠，能量消耗增加，对食源性肥胖及胰岛素耐受有抵抗性。
Plutzky称，未来的研究研究将是控制视黄醛水平的基因的变异，以及如何将那些控制视黄醛水平的通路作为药物治疗的目标。
专家提倡丰富、均衡饮食，称在没有监测的情况下，额外摄入任何维生素都将危害健康。 （丁香） 你的翻译很好呀.问题是英文原文就有问题,我已经查了,来源有两个:分别是http://cecentral.com/index.php?template=story&cID=54&nID=13560和http://www.medscape.com/viewarticle/557498;前者第一句的意思正和你意思相反,后者是一样的.你按原文翻译是对的.但原文本身就有问题. NEW YORK (Reuters Health) - Retinaldehyde (Rald), a metabolite of vitamin A, inhibits the generation of adipose tissue and increases insulin sensitivity, work conducted in a Harvard University laboratory shows.
Rald inhibitors, on the other hand, decrease fat tissue and diet-induced obesity, Drs. Jorge Plutzky and Ouliana Ziouzenkova and colleagues report in an advance online publication of Nature Medicine, released May 27, 2007.
"There is a growing realization that retinoids, as naturally occurring molecules derived from vitamin A, can play important and quite specific roles in controlling gene expression," Dr. Plutzky told Reuters Health. "Through this, retinoids can have key roles in controlling responses, such as energy balance, obesity and diabetes. Our work is an example of this trend."
The investigators' research showed that Rald is present in rodent fat, and that it binds to retinol-binding proteins, inhibits adipogenesis and suppresses peroxisome proliferators-activated receptor-gamma and retinoid X receptor (RXR) responses.
"Mice lacking the Rald-catabolizing enzyme retinaldehyde dehydrogenase 1 (Raldh1) resisted diet-induced obesity and insulin resistance and showed increased energy dissipation," the investigators announced.
"Now that we know retinaldehyde may play an important role in other locations outside the eye, including in locations like fat tissue, those pathways that control retinaldehyde levels could become targets for drug therapy," Dr. Plutzky said. "Likewise, variations in genes that control retinaldehyde levels may be involved in determining factors such as body weight, obesity and diabetes. These all represent future steps in our research which are ongoing and underway."
He cautioned that the results do not suggest a need for excess vitamin A supplementation. "A balanced well-rounded diet is always a good idea. Unmonitored excessive intake of any vitamin can be associated with health issues," he warned. 谢谢sunnygeng 战友提供原文。谢谢假行家战友指正。
NEW YORK (Reuters Health) - Retinaldehyde (Rald), a metabolite of vitamin A, inhibits the generation of adipose tissue and increases insulin sensitivity, work conducted in a Harvard University laboratory shows.
纽约(路透社报道) —— 哈佛大学研究结果表明，维生素A的代谢产物视黄醛可以抑制脂肪组织生成，增加胰岛素敏感性。
Rald inhibitors, on the other hand, decrease fat tissue and diet-induced obesity, Drs. Jorge Plutzky and Ouliana Ziouzenkova and colleagues report in an advance online publication of Nature Medicine, released May 27, 2007.
相反，5月27日提前在线发表的 Nature Medicine中，Jorge Plutzky博士、 Ouliana Ziouzenkova 博士及其同事称，视黄醛抑制剂可减少脂肪组织及食源性肥胖。
但是，这两句不还是矛盾的么？我又晕了。 一、是不是medscape抄错了？
http://www.medscape.com/viewarticle/557498
NEW YORK (Reuters Health) May 30 - Retinaldehyde (Rald), a metabolite of vitamin A, increases the generation of adipose tissue and decreases insulin sensitivity, work conducted in a Harvard University laboratory shows.
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作者:admin@医学,生命科学 2011-04-06 14:04
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