主页 > 医学新闻 >
【medical-news】联合抗生素疗法可有利于多发性硬
Medical Studies/Trials
Published: Tuesday, 11-Dec-2007
A preliminary study suggests that combining a medication currently used to treat multiple sclerosis with an antibiotic may slow the progress of the disease, according to an article posted online today that will appear in the February 2008 print issue of Archives of Neurology.
"Multiple sclerosis (MS) is an immune-mediated disorder that affects genetically susceptible individuals after exposure to certain, as yet unidentified environmental antigens," or disease-causing agents, the authors write as background information in the article. The development of MS involves inflammation that destroys parts of the brain along with progressive degeneration of brain tissue. The most common type is relapsing-remitting MS, in which patients experience attacks of symptoms such as muscle weakness and spasms followed by periods of symptom-free remission. Many patients with relapsing-remitting MS who take interferon, a medication that boosts the immune system and fights viruses, still experience relapses and may continue to develop new areas of damaged brain tissue (lesions) visible on magnetic resonance imaging (MRI).
Alireza Minagar, M.D., of Louisiana State University Health Sciences Center, Shreveport, and colleagues conducted a single-center trial involving 15 patients (average age 44.5) with relapsing-remitting MS who had been taking interferon for at least six months and were experiencing symptoms and developing new brain lesions. For four months, participants took 100 milligrams daily of the antibiotic doxycycline in addition to continuing interferon therapy. They underwent monthly neurological examinations, MRI to detect brain lesions and blood work to monitor safety.
After four months, the combination treatment resulted in fewer lesions visible on MRI-60 percent of the patients had more than a one-fourth reduction in the number of lesions from the beginning of the study. The patients also had reduced average scores on a scale designed to assess disability levels. Only one patient relapsed; adverse effects were mild and included only known effects of the two drugs individually rather than new effects associated with combining the medications.
Antibiotics in the tetracycline family, including doxycycline, may be effective against MS and other inflammatory diseases by inhibiting the action of enzymes that destroy certain nervous system cells, protecting the brain and increasing the effectiveness of the immune system, the authors note.
"There is growing interest in combination therapy in patients with MS to stabilize the clinical course, reduce the rate of clinical relapses and decelerate the progressive course of the underlying pathologic mechanism," they write. "Overall, data from this cohort suggest that the treatment combination of oral doxycycline and interferon beta-1a may be safe and effective in some patients with MS; however, further controlled clinical trials are warranted to demonstrate safety and efficacy in a larger patient population."
http://archneur.ama-assn.org/ 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Combination therapy including antibiotics may be beneficial for multiple sclerosis
联合抗生素疗法可有利于多发性硬化治疗
Medical Studies/Trials
Published: Tuesday, 11-Dec-2007
Translated by Whrilwind
A preliminary study suggests that combining a medication currently used to treat multiple sclerosis with an antibiotic may slow the progress of the disease, according to an article posted online today that will appear in the February 2008 print issue of Archives of Neurology.
根据一篇将会刊登在《Archives of Neurology》2008年2月刊的网络文章，初步研究提出联合抗生素及现用的治疗方案可减慢多发性硬化的病程进展。
"Multiple sclerosis (MS) is an immune-mediated disorder that affects genetically susceptible individuals after exposure to certain, as yet unidentified environmental antigens," or disease-causing agents, the authors write as background information in the article. The development of MS involves inflammation that destroys parts of the brain along with progressive degeneration of brain tissue. The most common type is relapsing-remitting MS, in which patients experience attacks of symptoms such as muscle weakness and spasms followed by periods of symptom-free remission. Many patients with relapsing-remitting MS who take interferon, a medication that boosts the immune system and fights viruses, still experience relapses and may continue to develop new areas of damaged brain tissue (lesions) visible on magnetic resonance imaging (MRI).
“多发性硬化（MS）是一种免疫介导的机体失衡，主要影响暴露于某些不明的环境抗原或致病因子的遗传性易感人群”，作者在文章背景资料中写道。多发性硬化病程发展包括炎症导致的伴随脑组织变性的部分脑损伤。最常见的类型是“复发－缓解型多发性硬化”，即病人在症状发作后，如肌无力和肌痉挛，有一段症状完全缓解的期间。许多复发－缓解型多发性硬化的病人服用干扰素（一种用于促进免疫系统及抗病毒的药物）后，仍会复发并可能继续出现核磁共振(MRI)上可见的新的脑组织损伤（脑损害）。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-02-23 17:11
医学,生命科学网