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【bio-news】维生素D与多发性硬化相关
Vitamin D, the principal regulator of calcium in the body, may prevent the production of malignant cells such as breast and prostate cancer cells and protect against specific autoimmune disorders including multiple sclerosis (MS) according to an article by Sylvia Christakos, PhD, of the UMDNJ-New Jersey Medical School.
In the article, Christakos reports that research shows that the incidence of MS decreases as the amount of vitamin D available to the body increases, either through sunlight exposure or diet. The article notes that MS is "for the most part, unknown in equatorial regions" and that the prevalence of the disease is lower in areas where fish consumption is high. The study is available online in the Journal of Cellular Biochemistry.
"Since vitamin D is produced in the skin through solar or UV irradiation and high serum levels have been shown to correlate with a reduced risk of MS, this suggests that vitamin D may regulate the immune response and may promote a host's reaction to a pathogen," Christakos said.
Christakos' report focuses on the immunosuppressive actions of the active form of vitamin D, which may inhibit the induction of MS, and emphasizes the importance of maintaining a sufficient vitamin D level.
"Evidence has shown that the maintenance of an adequate vitamin D level may have a protective effect in individuals predisposed to MS," Christakos said. "One device of vitamin D action may be to preserve balance in the T-cell reaction and thus avoid autoimmunity."
Despite the significant evidence of the benefits of vitamin D relative to MS and other autoimmune diseases, Christakos cautions that further studies are needed to determine whether vitamin D alone or combined with other treatments is effective in individuals with active MS.
The University of Medicine and Dentistry of New Jersey (UMDNJ) is the nation's largest free-standing public health sciences university with more than 5,500 students attending the state's three medical schools, its only dental school, a graduate school of biomedical sciences, a school of health related professions, a school of nursing and its only school of public health, on five campuses. Last year, there were more than two million patient visits to UMDNJ facilities and faculty at campuses in Newark, New Brunswick/Piscataway, Scotch Plains, Camden and Stratford. UMDNJ operates University Hospital, a Level I Trauma Center in Newark, and University Behavioral HealthCare, a mental health and addiction services network.
http://www.medicalnewstoday.com/articles/119109.php 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Study Highlights Link Between Vitamin D And Multiple Sclerosis
维生素D与多发性硬化高度相关
Vitamin D, the principal regulator of calcium in the body, may prevent the production of malignant cells such as breast and prostate cancer cells and protect against specific autoimmune disorders including multiple sclerosis (MS) according to an article by Sylvia Christakos, PhD, of the UMDNJ-New Jersey Medical School.
据新泽西牙科和医学大学—新泽西医学院的哲学博士Sylvia Christakos文章报道，维生素D是机体内钙的主要调节者，可以防止恶性细胞的产生，如乳腺和前列腺的癌细胞，并可以抵抗特异的自体免疫疾病，包括多发性硬化（MS）。
In the article, Christakos reports that research shows that the incidence of MS decreases as the amount of vitamin D available to the body increases, either through sunlight exposure or diet. The article notes that MS is "for the most part, unknown in equatorial regions" and that the prevalence of the disease is lower in areas where fish consumption is high. The study is available online in the Journal of Cellular Biochemistry.
在这篇文章中，Christakos报道的研究表明，不论是通过光照还是通过饮食摄入维生素D，随着机体可用的维生素D的量增加，多发性硬化的发病率降低。这篇文章注意到，多发性硬化通常在中纬线地区是不为人知的，这种病在鱼消耗量大的地区流行性较低。这篇文章已经在细胞生物化学杂志在线发表。
"Since vitamin D is produced in the skin through solar or UV irradiation and high serum levels have been shown to correlate with a reduced risk of MS, this suggests that vitamin D may regulate the immune response and may promote a host's reaction to a pathogen," Christakos said.
Christakos 说，“因为维生素D通过日光或紫外线辐射在皮肤中产生，血清中维生素D水平高与多发性硬化发病危险降低相关。这表明维生素D可能调节免疫反应，并促进机体对病原体的反应。”
Christakos' report focuses on the immunosuppressive actions of the active form of vitamin D, which may inhibit the induction of MS, and emphasizes the importance of maintaining a sufficient vitamin D level.
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作者:admin@医学,生命科学 2010-12-12 06:42
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