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【Stroke】血尿酸对认知功能的影响受缺血程度的
Cerebral Ischemia Mediates the Effect of Serum Uric Acid on Cognitive Function
Tracy D. Vannorsdall PhD; H. A. Jinnah MD, PhD; Barry Gordon MD, PhD; Michael Kraut MD, PhD; and David J. Schretlen PhD*
From the Department of Psychiatry and Behavioral Sciences (T.D.V., D.J.S.), the Russell H. Morgan Department of Radiology and Radiological Sciences (M.K., D.J.S.), and the Department of Neurology (H.A..J., B.G.), Johns Hopkins University School of Medicine, Baltimore, Md; and the Cognitive Science Department (B.G.), Johns Hopkins University, Baltimore, Md.
* To whom correspondence should be addressed. E-mail: dschret@jhmi.edu.
Background and Purpose—High normal concentrations of serum uric acid (UA) are associated with mild cognitive dysfunction and increased cerebral ischemia as indexed by white matter hyperintensity volumes. We hypothesized that individual differences in white matter hyperintensities mediate the association between UA and mild cognitive dysfunction.
Methods—One hundred eighty community-dwelling adults aged 20 to 96 years completed neuropsychological testing, laboratory blood studies, and a brain MRI scan.
Results—Serum UA was associated (P<0.05) with greater white matter hyperintensities and poorer working memory, processing speed, fluency, and verbal memory. Associations remained after controlling for age, sex, race, education, hypertension, diabetes, alcohol abuse, smoking, and body mass. Adding a term for white matter hyperintensity attenuated these associations such that UA no longer predicted cognitive performance.
Conclusions—Severity of cerebral ischemia might mediate the association between UA and cognitive dysfunction. Even mild elevations in UA appear to contribute to structural and functional brain changes. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Cerebral Ischemia Mediates the Effect of Serum Uric Acid on Cognitive Function
血尿酸对认知功能的影响受缺血程度的调节
Tracy D. Vannorsdall PhD; H. A. Jinnah MD, PhD; Barry Gordon MD, PhD; Michael Kraut MD, PhD; and David J. Schretlen PhD*
From the Department of Psychiatry and Behavioral Sciences (T.D.V., D.J.S.), the Russell H. Morgan Department of Radiology and Radiological Sciences (M.K., D.J.S.), and the Department of Neurology (H.A..J., B.G.), Johns Hopkins University School of Medicine, Baltimore, Md; and the Cognitive Science Department (B.G.), Johns Hopkins University, Baltimore, Md.
精神和行为学部(T.D.V., D.J.S.) 放射学部和放射学会(M.K., D.J.S.) 神经学部(H.A..J., B.G.) 约翰霍奇金医科大学Baltimore, Md 认知科学部(B.G.) 约翰霍奇金大学Baltimore, Md
* To whom correspondence should be addressed. E-mail: dschret@jhmi.edu.
通讯作者联系方式：E-mail: dschret@jhmi.edu.
Background and Purpose—High normal concentrations of serum uric acid (UA) are associated with mild cognitive dysfunction and increased cerebral ischemia as indexed by white matter hyperintensity volumes. We hypothesized that individual differences in white matter hyperintensities mediate the association between UA and mild cognitive dysfunction.
背景与目的：高尿酸血症与认知功能障碍以及脑循环缺血存在相关性。而白质密度的改变则反应了这一变化。由此我们认为白质密度对高尿酸血症与认知功能障碍之间的关系的影响存在个体差异。
Methods—One hundred eighty community-dwelling adults aged 20 to 96 years completed neuropsychological testing, laboratory blood studies, and a brain MRI scan.
方法：180名20岁至96岁的社区居民纳入研究，对所有研究对象进行神经生理学检查，实验室血液学分析和脑部MRI扫描。
Results—Serum UA was associated (P<0.05) with greater white matter hyperintensities and poorer working memory, processing speed, fluency, and verbal memory. Associations remained after controlling for age, sex, race, education, hypertension, diabetes, alcohol abuse, smoking, and body mass. Adding a term for white matter hyperintensity attenuated these associations such that UA no longer predicted cognitive performance.
结果：血浆UA与白质高密度、记忆力减退、运算速度降低、语言流畅性降低和语言记忆力下降具有显著相关性(P<0.05)。在排除年龄、性别、种族、教育程度、高血压、糖尿病、酗酒、吸烟和体重因素后以上相关性仍存在。而白质密度则削弱了这一关系，从而无法通过血浆尿酸浓推测认知功能。
Conclusions—Severity of cerebral ischemia might mediate the association between UA and cognitive dysfunction. Even mild elevations in UA appear to contribute to structural and functional brain changes.
结论：高尿酸血症和认知功能障碍可能受严重的脑缺血的影响。即使轻微的尿酸浓度升高也将会导致脑结构和功能的改变。 血尿酸对认知功能的影响受缺血程度的调节
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作者:admin@医学,生命科学 2010-11-30 05:11
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