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已发表的硕士论文的一部分,不过不是第一作者
摘 要 : 目的 研究肿瘤坏死因子、白介素 - 1 β在脑缺血 /再灌注损伤中的作用及雷公藤多糖甙对其影响。方法 用线栓法建立大鼠脑缺血 /再灌注动物模型 ,用放免法测定血清中肿瘤坏死因子 -α、白介素 - 1β的含量。结果 雷公藤多糖甙能抑制肿瘤坏死因子 - α、白介素 - 1 β的水平升高。结论 雷公藤多糖甙对大鼠局灶性脑缺血 /再灌注损伤有保护作用。
关键词 : 脑缺血 /再灌注 ; 雷公藤多糖甙 ; TNF-α; IL- 1β
中图分类号 :R743 . 3 文献标识码 :A
Changes of TNF- ︿ and IL- 1 ﹀ in focal cerebral ischemia- reperfusion injury in rats and effects of m ulti- glycosides of TWHF (GTW)on them F AN G Shu- you, LI Qing- jun, SON G Bo. (The First Aff iliated H ospital, Zhengzhou University, Zhengzhou450 0 52 , China)
Abstract: Objective To study the role of TNF and IL- 1 β on focal cerebral ischem ia- reperfusion injury in rats and the effects of multi- glycosides of TWHF (GTW)on them. Methods Rat cerebral ischemia- reperfusion
injury m odel was established with suture method. Using RIA method to determ ine TNF and IL- 1 β content in serum . Results This study showed that GTW could reduce the production of TNF and IL- 1β. Conclusion GTW possesses protective effect on focal cerebral ischemia- reperfusion injury in rat.
Key words: Ischemia- reperfusion injury; GTW; TNF- α; IL- 1 β
雷公藤多糖甙对大鼠局灶性脑缺血再灌注损伤中IL-1β和TNF-α的影响.caj (80.75k)
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作者:admin@医学,生命科学 2010-11-29 05:11
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