主页 > 医学新闻 >
【medical-news】流感病毒复制的关键步骤
U of S Vaccine and Infectious Disease Organization team discovers key step in flu virus replication
As public health officials around the world keep a nervous eye on the spread of avian influenza, the University of Saskatchewan's Vaccine and Infectious Disease Organization (VIDO) has uncovered a key step in how the influenza virus causes infection.
Yan Zhou and her team have discovered how a crucial pathway that supports the influenza A virus's ability to reproduce itself is activated, a finding that could pave the way for new drugs and vaccines.
The paper will appear in the January 2007 issue of the Journal of General Virology and recently has been given advance on-line publication.
"The work we are doing will be applicable to all influenza viruses, including influenza A virus subtype H5N1," said VIDO Director Lorne Babiuk.
Zhou says that although years of research remain to be done, this work provides novel insights for developing live vaccines and antiviral drugs for influenza epidemics and pandemics. A provisional patent has been filed on the findings.
"Given the health, economic and social consequences of influenza epidemics, the work of Dr. Zhou and her team demonstrates the importance of building influenza research capacity in Canada," said Dr. Bhagirath Singh, Scientific Director of the CIHR Institute of Infection and Immunity.
"Their research findings may help to develop new influenza treatments and prevent the disease, as well as add to global pandemic preparedness research."
To survive, the influenza virus hijacks the host animal or human's cellular machinery and forces it to make more copies of the virus. The researchers believe that the cellular events involved in this process are an excellent target for interventions against influenza.
The study revealed novel characteristics of a protein, called NS1, that activates a key pathway in the virus's reproduction. This information will help the researchers learn how to create harmless influenza viruses that can be used as live vaccines.
The pathway can be thought of as an assembly line with a switch to turn it on, says Zhou. "If the switch is turned on, the pathway enables efficient production of more viruses. But only the NS1 protein can turn on the switch."
The researchers are investigating genes and proteins of the influenza viruses of swine, horses and birds to see how they activate downstream cellular signalling pathways. To do this, they are using reverse genetics technology, where researchers begin with a gene and figure out its function.
These studies will allow the team to identify the genes that enable the virus to cause disease, laying the groundwork for antiviral drug development.
"Increasingly, new diseases involve both humans and animals," said Andrew Potter,VIDO's Associate Director (Research). "VIDO's background in veterinary research means that when diseases like avian influenza develop, we have the resources to begin studying the disease fairly quickly." 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 U of S Vaccine and Infectious Disease Organization team discovers key step in flu virus replication
美国疫苗和传染病机构小组发现了流感病毒复制的关键步骤
As public health officials around the world keep a nervous eye on the spread of avian influenza, the University of Saskatchewan's Vaccine and Infectious Disease Organization (VIDO) has uncovered a key step in how the influenza virus causes infection.
由于世界卫生公共部门一直很关注禽流感的扩散，Saskatchewan大学的疫苗和传染病机构已经揭示了禽流感如何导致传染的关键步骤。
Yan Zhou and her team have discovered how a crucial pathway that supports the influenza A virus's ability to reproduce itself is activated, a finding that could pave the way for new drugs and vaccines.
Yan Zhou和她的工作小组发现了一个关键步骤是如何支持流行性感冒A病毒的复制功能的。这一发现对新药和新疫苗的研发有辅助作用。
The paper will appear in the January 2007 issue of the Journal of General Virology and recently has been given advance on-line publication.
这一论文将发表在2007年1月的普通病毒学杂志上，最近已有网上的版本。
"The work we are doing will be applicable to all influenza viruses, including influenza A virus subtype H5N1," said VIDO Director Lorne Babiuk.
“我们的工作对所有的流感病毒都适用，包括流感病毒A亚型H5N1，”VIDO的负责人Lorne Babiuk说。
Zhou says that although years of research remain to be done, this work provides novel insights for developing live vaccines and antiviral drugs for influenza epidemics and pandemics. A provisional patent has been filed on the findings.
阅读本文的人还阅读：
作者:admin@医学,生命科学 2010-10-10 17:11
医学,生命科学网