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【bio-news】IL-6：卫星细胞介导的骨骼肌肥大的必
Skeletal muscles adapt to increasing workload by augmenting their fiber size, through mechanisms that are poorly understood.
This study identifies the cytokine interleukin-6 (IL-6) as an essential regulator of satellite cell (muscle stem cell)-mediated hypertrophic muscle growth. IL-6 is locally and transiently produced by growing myofibers and associated satellite cells, and genetic loss of IL-6 blunted muscle hypertrophy in vivo. IL-6 deficiency abrogated satellite cell proliferation and myonuclear accretion in the preexisting myofiber by impairing STAT3 activation and expression of its target gene cyclin D1. The growth defect was indeed muscle cell intrinsic, since IL-6 loss also affected satellite cell behavior in vitro, in a STAT3-dependent manner. Myotube-produced IL-6 further stimulated cell proliferation in a paracrine fashion.
These findings unveil a role for IL-6 in hypertrophic muscle growth and provide mechanistic evidence for the contribution of satellite cells to this process.
http://www.cellmetabolism.org/content/article/abstract?uid=PIIS155041310700366X
作者单位
1 Program on Differentiation and Cancer, Center for Genomic Regulation (CRG) and Center for Neurodegenerative Diseases (CIBERNED), Pompeu Fabra University, E-08003 Barcelona, Spain 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 IL-6：卫星细胞介导的骨骼肌肥大的必要调控因子
骨骼肌通过增粗肌纤维来适应更大的工作量，但是具体机制不详。这项研究发现IL-6是卫星细胞介导的骨骼肌肥大的必要调控因子。在体内，IL-6由生长的肌纤维细胞及相关卫星细胞于本位瞬时分泌，IL-6基因缺乏的肌肉组织无法增生。在预先存在的肌纤维中，IL-6缺乏通过减弱STAT3 及其靶基因cyclin D1使卫星细胞和肌细胞核不再增殖。这种缺陷是肌肉本身的，因为IL-6缺乏也影响到了卫星细胞在体外，通过STAT3依赖方式。肌管旁分泌IL-6进一步刺激细胞增殖。
这项发现揭示了IL-6在肌肉增生中的作用，并为卫星细胞在此过程中的作用提供了证据。 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-07-05 05:52
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