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【drug-news】NIH将评估抗氧化剂和鱼油联合治疗A
Nearly 100 clinical centers are now seeking 4,000 study participants
The National Institutes of Health (NIH) announces a nationwide study to see if a modified combination of vitamins, minerals, and fish oil can further slow the progression of vision loss from AMD, the leading cause of vision loss in the United States for people over age 60. This new study, called the Age-Related Eye Disease Study 2 (AREDS2), will build upon results from the earlier Age-Related Eye Disease Study (AREDS). The original study results were released five years ago today. The study found that high-dose antioxidant vitamins and minerals (vitamins C and E, beta-carotene, zinc, and copper), taken by mouth, reduced the risk of progression to advanced AMD by 25 percent, and the risk of moderate vision loss by 19 percent.
AREDS2 will refine the findings of the original study by adding lutein and zeaxanthin (plant-derived yellow pigments that accumulate in the macula, the small area responsible for central vision near the center of the retina) and the omega-3 fatty acids DHA and EPA (derived from fish and vegetable oils) to the study formulation. The main study objective is to determine if these nutrients will decrease a person's risk of progression to advanced AMD, which often leads to vision loss. Previous observational studies have suggested these nutrients may protect vision.
"Vision loss from AMD is an important public health issue. This study may help us find a better way to treat this devastating disease," said Elias A. Zerhouni, M.D., director of the NIH.
AMD damages the macula. As the disease progresses, it blurs the patient's central vision. AMD can take two forms, wet and dry. Wet AMD is caused by the abnormal growth of blood vessels under the macula. This leads to rapid loss of central vision. Wet AMD is considered to be advanced AMD and is more severe than the dry form. Dry AMD, the more common form, occurs when the light-sensitive cells in the macula slowly break down. Untreated dry AMD can progress into wet AMD.
Paul A. Sieving, M.D., Ph.D., director of the National Eye Institute (NEI) at NIH, said, "Nearly two million Americans have vision loss from advanced AMD, and another seven million with AMD are at substantial risk for vision loss. In the AREDS study, we found a combination of vitamins and minerals that effectively slowed the progression of AMD for some people. Now, we will conduct this more precisely-targeted study to see if the new combination of nutrients can reduce AMD progression even further. This study may help people at high risk for advanced AMD maintain useful vision for a longer time."
Emily Y. Chew, M.D., study chair and deputy director of the Division of Epidemiology and Clinical Research at the NEI said, "The AREDS2 study is seeking 4,000 people between 50 and 85 years of age with AMD in both eyes, or advanced AMD in one eye. They must be available for yearly eye examinations for at least five years. Until we get the results from AREDS2, we encourage people with AMD to visit their eye care professional to see if they need to take the AREDS vitamin and mineral formulation. This alone could save more than 300,000 people from vision loss over the next five years." 认领！！！
感觉还蛮有意思，下午再来完成作业，嘿嘿！ 美国国家卫生研究院将评估抗氧化剂和鱼油联合治疗AMD的疗效
新一轮的全国范围调查将评估抗氧化剂和鱼油联合治疗AMD（老年黄斑病变）的疗效。
对所需的4000名受试者，现在已有将近100所临床研究中心在进行招募工作。
国家卫生研究院展开全国范围调查，目的在于研究能否更好的使维生素、矿物质和鱼油联合作用，进而进一步延缓由AMD病造成的低视力损害——在美国，该病是60多岁人中致盲的首要病因。该研究基于早期的一项“老年相关性眼病研究”被称为“二号老年相关性眼病研究”。早在五年前，原始的早期研究结果就已公布：口服高剂量的抗氧剂维生素和矿物质（维生素C和E、Beta类胡萝卜素、锌和铜）可使AMD病的进程减缓25%，是中度失明减少19%。
二号老年相关性眼病研究将对原有研究结果进行完善，增加了叶黄素和玉米黄质（一种植物中提取的黄色色素，堆积成“斑”，在临近视网膜的视觉中枢，与视力密切相关）；奥米加3脂肪酸 二十二碳六烯酸(DHA)和二十碳五烯酸(EPA)（在鱼油和蔬菜有中提取）。研究的主要目的在于确认这些营养物质能否真的减缓AMD病进一步发展为失明。先前的研究显示他们可能对视力有保护作用。
“由老年黄斑病变所致失明作为公共健康的主要课题，该研究有望帮助我们找到治疗这一恶疾更好的方法。”美国国家卫生研究院院长 Elias A. Zerhouni, M.D.如是说。
坏了“斑”，随着病情发展，它会损害患者的视觉中枢。该病有干性和湿性之分，湿性病变是由视网膜不正常的血管所致，能快速干扰视觉中枢，被认为是老年黄斑病变晚期，较干性病变更为严重。干性病变更为普遍，当斑物质的低敏感细胞退化，就会发病。干性病变不予以治疗就会发展为湿性病变。
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作者:admin@医学,生命科学 2011-07-22 18:41
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