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【文摘发布】冠心病患者更易罹患结肠直肠癌
Author: Annie On On Chan, MD, PhD; Man Hong Jim, MD; Kwok Fai Lam, PhD;et al
Resource: JAMA. 2007;298:1412-1419.
Context Colorectal neoplasm and coronary artery disease (CAD) share similar risk factors, and their co-occurrence may be associated.
Objectives To investigate the prevalence of colorectal neoplasm in patients with CAD in a cross-sectional study and to identify the predisposing factors for the association of the 2 diseases.
Design, Setting, and Participants Patients in Hong Kong, China, were recruited for screening colonoscopy after undergoing coronary angiography for suspected CAD during November 2004 to June 2006. Presence of CAD (n = 206) was defined as at least 50% diameter stenosis in any 1 of the major coronary arteries; otherwise, patients were considered CAD-negative (n = 208). An age- and sex-matched control group was recruited from the general population (n = 207). Patients were excluded for use of aspirin or statins, personal history of colonic disease, or colonoscopy in the past 10 years.
Main Outcome Measures The prevalence of colorectal neoplasm in CAD-positive, CAD-negative, and general population participants was determined. Bivariate logistic regression was performed to study the association between colorectal neoplasm and CAD and to identify risk factors for the association of the 2 diseases after adjusting for age and sex.
Results The prevalence of colorectal neoplasm in the CAD-positive, CAD-negative, and general population groups was 34.0%, 18.8%, and 20.8% (P < .001 by {chi}2 test), prevalence of advanced lesions was 18.4%, 8.7%, and 5.8% (P < .001), and prevalence of cancer was 4.4%, 0.5%, and 1.4% (P = .02), respectively. Fifty percent of the cancers in CAD-positive participants were early stage. After adjusting for age and sex, an association still existed between colorectal neoplasm and presence of CAD (odds ratio [OR], 1.88; 95% confidence interval [CI], 1.25-2.70; P = .002) and between advanced lesions and presence of CAD (OR, 2.51; 95% CI, 1.43-4.35; P = .001). The metabolic syndrome (OR, 5.99; 95% CI, 1.43-27.94; P = .02) and history of smoking (OR, 4.74; 95% CI, 1.38-18.92; P = .02) were independent factors for the association of advanced colonic lesions and CAD.
Conclusions In this study population undergoing coronary angiography, the prevalence of colorectal neoplasm was greater in patients with CAD. The association between the presence of advanced colonic lesions and CAD was stronger in persons with the metabolic syndrome and a history of smoking. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 Title: Prevalence of Colorectal Neoplasm Among Patients With Newly Diagnosed Coronary Artery Disease
题目：冠心病患者更易罹患结肠直肠癌
Author: Annie On On Chan, MD, PhD; Man Hong Jim, MD; Kwok Fai Lam, PhD;et al
Resource: JAMA. 2007;298:1412-1419.
Context Colorectal neoplasm and coronary artery disease (CAD) share similar risk factors, and their co-occurrence may be associated.
结肠直肠癌和冠心病具有相同的危险因素，两者伴随出现可能是有关系的。
Objectives To investigate the prevalence of colorectal neoplasm in patients with CAD in a cross-sectional study and to identify the predisposing factors for the association of the 2 diseases.
一个有代表性的研究客观的调查了冠心病患者中结肠直肠癌的患病率，以确定联系两种疾病的素因性因素。
Design, Setting, and Participants Patients in Hong Kong, China, were recruited for screening colonoscopy after undergoing coronary angiography for suspected CAD during November 2004 to June 2006. Presence of CAD (n = 206) was defined as at least 50% diameter stenosis in any 1 of the major coronary arteries; otherwise, patients were considered CAD-negative (n = 208). An age- and sex-matched control group was recruited from the general population (n = 207). Patients were excluded for use of aspirin or statins, personal history of colonic disease, or colonoscopy in the past 10 years.
在中国香港，从2004年11月到2006年6月对冠状动脉造影怀疑CAD的受试者做结肠镜检查。将任何一主要冠状动脉内径50%以上狭窄者定义为CAD患者，该组206人。其他的为非CAD患者，共208人。与之性别年龄相应的对照组从一般人群中选取，共207人。受试者不使用阿司匹林和他汀类药物，没有其他慢性疾病，在过去10年没有做过结肠镜检查。
Main Outcome Measures The prevalence of colorectal neoplasm in CAD-positive, CAD-negative, and general population participants was determined. Bivariate logistic regression was performed to study the association between colorectal neoplasm and CAD and to identify risk factors for the association of the 2 diseases after adjusting for age and sex.
在CAD阳性组、CAD阴性组及对照组结肠直肠癌的患病率都是确定的，在调整了年龄性别等因素后用Bivariate逻辑回归分析结肠直肠癌与CAD间的联系，以确定联系两种疾病的危险因素。
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作者:admin@医学,生命科学 2011-07-29 17:12
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