主页 > 医学前沿 >
【medical-news】幽门螺旋杆菌提高了下部胃癌的发
Helicobacter pylori increases risk of lower stomach cancer, decreases risk of upper
The bacteria Helicobacter pylori substantially increase the risk of cancer in the lower stomach, but it may decrease the risk of cancer near the junction between the esophagus and the stomach, according to a study in the October 19 Journal of the National Cancer Institute.
This finding may help explain the changing rates and distributions of these cancers in Western countries over the past century.
Infection with H. pylori, which is known to cause ulcers, has also been associated with certain types of gastric cancer, but the strength of association varies with where the cancer is located in the stomach. Two types of gastric cancer commonly exist -- cardia, or cancer of the upper stomach joining the esophagus; and noncardia, or cancer of the lower stomach.
A group of researchers led by Farin Kamangar, M.D., Ph.D., of the National Cancer Institute in Bethesda, Md., selected 234 cardia and noncardia gastric cancer patients in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study and matched them to controls. They assessed all of the subjects for H. pylori infection by testing their blood for antibodies that indicate prior infection.
The authors found that the subjects infected with H. pylori had a higher risk of developing noncardia gastric cancer and a lower risk of developing cardia gastric cancer. They suggest that a decrease in H. pylori infections during the past century may be one reason that scientists have observed increasing rates of cardia and decreasing rates of noncardia gastric cancers in Western countries.
"The results of this study suggest that caution may be warranted against mass treatment to eradicate H. pylori ," the authors write.
In an accompanying editorial, Olof Nyren, M.D., Ph.D., of the Karolinska Institute in Sweden, and William J. Blot, Ph.D., of the International Epidemiology Institute in Rockville, Md., write, "It seems prudent to include the putative protective effect of H. pylori against adenocarcinoma of the esophagus or cardia in the equation when drawing up prevention plans for gastric cancer." 认领... Helicobacter pylori increases risk of lower stomach cancer, decreases risk of upper
Medical Studies/Trials
Published: Tuesday, 17-Oct-2006
The bacteria Helicobacter pylori substantially increase the risk of cancer in the lower stomach, but it may decrease the risk of cancer near the junction between the esophagus and the stomach, according to a study in the October 19 Journal of the National Cancer Institute.
幽门螺旋杆菌大大提高了下部胃发生肿瘤的风险，而可能降低了食管和胃移行部位附近发生肿瘤的风险，十月刊第十九期国立癌症研究所杂志报道。
This finding may help explain the changing rates and distributions of these cancers in Western countries over the past century.
此研究有助于解释上世纪西部国家此类肿瘤的发生率和分布不断变化的原因。
Infection with H. pylori, which is known to cause ulcers, has also been associated with certain types of gastric cancer, but the strength of association varies with where the cancer is located in the stomach. Two types of gastric cancer commonly exist -- cardia, or cancer of the upper stomach joining the esophagus; and noncardia, or cancer of the lower stomach.
众所周知，幽门螺旋菌感染可引起溃疡，与某些类型的胃癌也有关，然而，与感染有关的胃癌的发生部位是有差异的。两种类型的胃癌常发生在贲门，或与食道相接的胃上部、非贲门区以及胃下部。
A group of researchers led by Farin Kamangar, M.D., Ph.D., of the National Cancer Institute in Bethesda, Md., selected 234 cardia and noncardia gastric cancer patients in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study and matched them to controls. They assessed all of the subjects for H. pylori infection by testing their blood for antibodies that indicate prior infection.
国立癌症研究所医学博士、公共卫生博士Farin Kamangar,带领的研究小组，选择234例贲门癌和非贲门区肿瘤患者，根据α生育酚和β胡萝卜素两种预防方法进行分类对照研究。通过检测血液中的相关抗体，对受试者的幽门螺旋杆菌感染情况进行评估。
The authors found that the subjects infected with H. pylori had a higher risk of developing noncardia gastric cancer and a lower risk of developing cardia gastric cancer. They suggest that a decrease in H. pylori infections during the past century may be one reason that scientists have observed increasing rates of cardia and decreasing rates of noncardia gastric cancers in Western countries.
研究者发现，幽门螺旋杆菌感染者有较高的患非贲门区肿瘤的风险，较低的患贲门肿瘤的风险。他们说，降低幽门螺旋杆菌感染，可能是引起上世纪西部国家贲门区肿瘤发生率增高而非贲门区肿瘤发生率下降的原因之一。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-07-09 12:01
医学,生命科学网