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【medical-news】孕妇的腹部脂肪与出生缺陷风险相
NEW YORK (Reuters Health) - Women who are obese before they become pregnant may be at increased risk of having a baby with defects of the brain and spinal cord, especially if they tend to put on weight around the waist, according to new research from the March of Dimes.
But a woman's body mass index (BMI) before pregnancy had no relationship to her likelihood of having a child with certain types of heart malformation, Drs. Gary M. Shaw and Susan Carmichael of the Children's Hospital Oakland Research Institute in California found.
Previous studies have linked maternal obesity to a number of birth defects, especially neural tube defects, which are malformations of the brain and spinal cord, Shaw and Carmichael note in the journal Epidemiology. The most common neural tube defects are spina bifida, in which the spinal cord fails to close completely during fetal development, and anencephaly, in which part or all of the brain doesn't develop.
To examine the relationship between obesity and other weight-related factors in the risk of these and other birth defects, the researchers looked at 700 women who gave birth to healthy children and 659 who delivered babies with spina bifida, anencephaly, a type of heart malformation called transposition of great arteries, or a different heart defect known as tetralogy of Fallot.
There was no association with prepregnancy BMI and either heart defect. Women with BMIs of 30 or greater were 60 percent more likely to have a child with anencephaly and 40 percent more likely to have a baby with spina bifida than their slimmer peers. But babies born to mothers who said that they had gained weight around their waists rather than their hips were 2.4 times as likely to have anencephaly and at 1.8 fold greater risk of spina bifida.
Abdominal weight gain may play a role in the development of type 2 diabetes, the researchers note. "Thus, this finding may offer a clue to underlying mechanisms for the associations of obesity with birth defect risk, given that clinical diabetes is also a risk factor for birth defects," they write.
SOURCE: Epidemiology, July 2008.
http://www.reuters.com/article/healthNews/idUSREE58063020080725 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Mom's abdominal fat linked with birth defect risk
孕妇的腹部脂肪与先天缺陷风险相关
NEW YORK (Reuters Health) - Women who are obese before they become pregnant may be at increased risk of having a baby with defects of the brain and spinal cord, especially if they tend to put on weight around the waist, according to new research from the March of Dimes.
纽约（路透社健康版）－根据一项新研究发现，女人在她们怀孕前就肥胖的可能会生脑或脊髓缺陷的孩子的危险度在增加，尤其是如果她们倾向于腰部肥胖。
But a woman's body mass index (BMI) before pregnancy had no relationship to her likelihood of having a child with certain types of heart malformation, Drs. Gary M. Shaw and Susan Carmichael of the Children's Hospital Oakland Research Institute in California found.
但是加州奥克兰研究所儿童医院的Gary M. Shaw博士和Susan Carmichael博士发现，女人怀孕前的体重指数与生心脏畸形孩子的可能性没有关系。
Previous studies have linked maternal obesity to a number of birth defects, especially neural tube defects, which are malformations of the brain and spinal cord, Shaw and Carmichael note in the journal Epidemiology.
以前的研究已经把母亲的体重和大量的先天性缺陷联系起来，尤其是脑或脊髓畸形的神经管缺陷，Shaw和 Carmichael在流行病学杂志上写道。
The most common neural tube defects are spina bifida, in which the spin al cord fails to close completely during fetal development, and anencephaly, in which part or all of the brain doesn't develop.
最常见的神经管缺陷是脊柱裂，它是指胎儿期脊髓没有被完全封闭，和无脑畸形，它指部分或全部脑组织没有发育。
To examine the relationship between obesity and other weight-related factors in the risk of these and other birth defects, the researchers looked at 700 women who gave birth to healthy children and 659 who delivered babies with spina bifida, anencephaly, a type of heart malformation called transposition of great arteries, or a different heart defect known as tetralogy of Fallot.
为了检查这几种先天缺陷和其他先天缺陷疾病的危险中，肥胖与其他体重相关因素的关系，研究者们观察了700位生健康宝宝的母亲和659位生有脊柱裂、无脑畸形、大动脉扭转或法洛四联征等有先天缺陷婴儿的母亲。
There was no association with prepregnancy BMI and either heart defect. Women with BMIs of 30 or greater were 60 percent more likely to have a child with anencephaly and 40 percent more likely to have a baby with spina bifida than their slimmer peers.
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作者:admin@医学,生命科学 2011-07-04 18:05
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