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（Science News －－编译 ）哮喘患者的免疫系统对不
4-Apr-2005
哮喘患者的免疫系统对不同的致敏原反应不同
墨西哥Chihuahua大学研究人员报道哮喘患者的免疫系统对不同的致敏原反应不同，仰赖于患季节过敏性鼻炎或没有过敏性症状的时候他们的白血球是否已经反应。
进行这项研究的Irene Leal-Berumen 博士在4月2日San Diego的会议上说这项研究的成果是人性化治疗过敏症和哮喘第一个重要的步骤，而这两种疾病是世界性的并严重影响生活质量和加重人们的经济负担。
哮喘是一种慢性阻塞性肺脏疾病，它的症状包括喘息,咳嗽,呼吸困难等。哮喘发作通常由上呼吸道感染,运动，过冷过热的天气变化和化学刺激物以及导致季节过敏反应的花粉，螨虫，蟑螂，羽毛，动物毛皮和其他的过敏原引起。 实际上，许多哮喘患者都有1到两种过敏原,并导致打喷嚏，眼痒，鼻塞等症状。
所有人的过敏反应都是以白细胞对抗外来刺激引起的。白细胞产生细胞活性物质参加免疫炎症反应。虽然哮喘和过敏症有相同的病因和发病方式,但他们的治疗反应不同。
研究包括10个临床诊断过敏性鼻炎的患者,有或没有哮喘。外周血白细胞在有鼻炎症状和没有鼻炎症状的时候, 分别进行前列腺素的检查。十个哮喘患者中的九个白血球产生大量的细胞介素 IL-5 ，九个哮喘患者中的五个产生细胞介素IL-13 ，这些结果显示相同的患者白细胞产生IL-13 或 IL-5 仰赖于是否存在过敏性鼻炎症状
Leal-Berumen博士说他们打算研究细胞对更多过敏原产生前列腺素的反应，这些研究将会促进更好地理解哮喘和其他的过敏性疾病并指导遗传药理治疗的进展。
原文：
http://www.medicalnewstoday.com/medicalnews.php?newsid=22177
Asthma patients' immune systems respond differently with allergies
Researchers from the University of Chihuahua in Mexico report that immune systems of patients with asthma responded differently to a common laboratory challenge, depending on whether their white blood cells had been obtained during a time when they were suffering from common season allergic rhinitis or when they were free of such allergic symptoms.
The study was presented by Dr. Irene Leal-Berumen on Saturday, April 2, at The American Association of Immunologists scientific sessions during Experimental Biology 2005 in San Diego. She says the findings are an important first step to personalizing treatments for allergy and asthma, both worldwide diseases that interfere with life quality and generate high economic burden.
Asthma is a chronic obstructive inflammatory lung disease with symptoms including wheezing, coughing, chest tightness, and shortness of breath. Asthma attacks can be triggered by viral upper respiratory infections, exercise, extreme temperature condition, and chemical irritants - and also by the same allergens that cause seasonal allergies to pollen or mold spore or perennial allergies to dust mites, cockroaches, feathers, animal fur and other allergens. In fact, the vast majority of patients with asthma also experience one or both of these forms of allergy, with the same symptoms of frequent sneezing, itchy eyes, runny nose and nasal stuffiness.
In people with and without asthma, the body's response to allergens is based in the leukocytes, or white blood cells, that rush to defend the body against foreign agents. The leukocytes produce cytokines that mediate and regulate immunity and inflammation to an immune stimulus. Because people with asthma and allergy share this common etiological pathway, they show different expressions of their disease with a wide variety of therapeutic responses. That's why Dr. Leal-Berumen's laboratory became interested in studying the different response of these cytokines in asthma patients when they were and were not experiencing allergies.
The study involved 10 patients with clinical diagnosis for allergic rhinitis, who also have or had had asthma. Peripheral blood leucocytes were obtained both during rhinitis symptoms and during a period when the patients were not experiencing rhinitis symptoms, then cultured with a type of prostaglandin, a substance that causes inflammation. In nine of the ten asthma patients, leucocytes produced a greater amount of the cytokine IL-5 when isolated during the no symptoms season, whereas five of the nine showed a greater production of IL-13, another cytokine, during the symptoms season. These results indicate that leucocytes from the same patient present different susceptibility to IL-5 and IL-13 production depending on the presence or absence of allergic rhinitis symptoms.
Dr. Leal-Berumen says the group now plans to study cell response to more specific allergens similar to what was done with the prostaglandin challenge. They believe these studies will contribute to a better understanding of asthma, allergy and other inflammatory disease and guide the pharmacogenetic development of new therapies.
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作者:admin@医学,生命科学 2011-05-05 17:01
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