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【编译】胚胎干细胞“打造”生物起搏器
出处:Nature Biotechnology 22, 1282 - 1289 (2004)
作者zhak Kehat1, 3, Leonid Khimovich1, Oren Caspi1, Amira Gepstein1, Rona Shofti1, Gil Arbel1, Irit Huber1, Jonathan Satin5, Joseph Itskovitz-Eldor4 & Lior Gepstein1, 2, 3
摘要:Cell therapy is emerging as a promising strategy for myocardial repair. This approach is hampered, however, by the lack of sources for human cardiac tissue and by the absence of direct evidence for functional integration of donor cells into host tissues. Here we investigate whether cells derived from human embryonic stem (hES) cells can restore myocardial electromechanical properties. Cardiomyocyte cell grafts were generated from hES cells in vitro using the embryoid body differentiating system. This tissue formed structural and electromechanical connections with cultured rat cardiomyocytes. In vivo integration was shown in a large-animal model of slow heart rate. The transplanted hES cell–derived cardiomyocytes paced the hearts of swine with complete atrioventricular block, as assessed by detailed three-dimensional electrophysiological mapping and histopathological examination. These results demonstrate the potential of hES-cell cardiomyocytes to act as a rate-responsive biological pacemaker and for future myocardial regeneration strategies.
译文:把细胞治疗运用于心脏损伤的修复是一个巨大的进步，由人体胚胎干细胞生成的细胞能够调整猪的心律。我们在培养皿中利用人体胚胎干细胞生成心脏细胞，然后将这些细胞移植到一只心动过缓的猪体内。结果移植的人体心脏细胞宛如生物版的电子起搏器，部分修正了猪心脏的异常。移植人体细胞发挥的起搏器作用表明，它们已经成为受体猪心脏的一部分，同时也展示了人体胚胎干细胞在修复心脏方面的潜力。据此我们提出，细胞治疗可以作为常规机械起搏器的补充。 这是极好的思路，只有思路才会有出路！ 我好象听说已有很多家医院开展了这方面的临床研究和应用。 全文下载 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-04-23 05:14
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