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【medical-news】大剂量维生素D显著改善癫痫患者骨
By Will Boggs
NEW YORK (Reuters Health) Dec 18 - High-dose vitamin D therapy significantly improves bone mineral density (BMD) in adults and children on long-term anticonvulsants, according to the findings of two parallel randomized, controlled trials published in the December issue of Neurology.
"Many factors affect vitamin D metabolism, such as ethnicity, gender, geographic location, nutritional and lifestyle habits, and type and duration of antiepileptic drug use," Dr. Ghada El-Hajj Fuleihan from American University of Beirut Medical Center, told Reuters Health. "High doses of vitamin D are beneficial in high-risk patients."
Dr. Fuleihan and colleagues compared the effects of low-dose (400 IU/day) and high-dose (2000 IU/day, children; 4000 IU/day, adults) vitamin D on bone mineral density in 72 adults and 78 children and adolescents taking anticonvulsant medications.
Thirty-four percent of the adults were in the deficient range and 46% were in the insufficient range of vitamin D levels at baseline, the authors report, and 18% of children were in the deficient range and 44% in the insufficient range.
BMD in the adults was below that of normal young controls, the results indicate, but BMD in the children and adolescents did not differ significantly from that of controls.
After treatment, none of the adults in the high-dose group remained vitamin D deficient and only 31% had vitamin D insufficiency, the researchers note. Only 6% of the overall pediatric group was vitamin D deficient and 44% were vitamin D insufficient.
BMD in adults assigned to high-dose vitamin D increased significantly in the lumbar spine, total hip, and radius, the report indicates. BMD did not change significantly in the low-dose vitamin D group.
BMD also increased at several sites in children treated with both doses of vitamin D, the researchers say, with no differences between the dose groups.
Despite the improvements in adults, BMD at all skeletal sites remained below young adult controls after 1 year of vitamin D therapy.]
"Until further studies are conducted in ambulatory patients, the measurement of a baseline 25-hydroxyvitamin D level, and its monitoring aiming for a 25-25-hydroxyvitamin D level > 30 ng/mL, may be the best guide for the dose of vitamin D to be used," Dr. Fuleihan said.
"For adults with a 25-hydroxyvitamin D level below 25 ng/mL, the equivalent of 4000 IU/day would reach that aim, whereas for those with more replete vitamin D levels, the use of 400-600 IU/day may be sufficient."
"Current data do not allow such specific recommendations in children, though a minimum of 800 IU/day is safe and may be protective to bone," Dr. Fuleihan added.
http://www.medscape.com/viewarticle/549525 这篇文章可能选题不太好，没人认领，我自己译吧！
High-Dose Vitamin D Improves Bone Density in Patients on Anticonvulsants
大剂量维生素D改善癫痫患者骨密度
By Will Boggs
NEW YORK (Reuters Health) Dec 18 - High-dose vitamin D therapy significantly improves bone mineral density (BMD) in adults and children on long-term anticonvulsants, according to the findings of two parallel randomized, controlled trials published in the December issue of Neurology.
纽约（路透社健康版）12月18日－据发表在《Neurology》12月刊的两组平行随机对照研究报道，长期服用抗癫痫药的成人和儿童应用受大剂量维生素D 可以显著改善其骨密度（BMD）。
"Many factors affect vitamin D metabolism, such as ethnicity, gender, geographic location, nutritional and lifestyle habits, and type and duration of antiepileptic drug use," Dr. Ghada El-Hajj Fuleihan from American University of Beirut Medical Center, told Reuters Health. "High doses of vitamin D are beneficial in high-risk patients."
贝鲁特美国大学医学中心的Ghada El-Hajj Fuleihan 博士告诉路透社，“许多因素影响维生素D代谢，例如种族、性别、地理环境、营养、生活习惯、服用抗癫痫药的种类和持续时间等，大剂量维生素D对高危患者有益。”
Dr. Fuleihan and colleagues compared the effects of low-dose (400 IU/day) and high-dose (2000 IU/day, children; 4000 IU/day, adults) vitamin D on bone mineral density in 72 adults and 78 children and adolescents taking anticonvulsant medications.
Fuleihan博士和他的同事对服用抗癫痫药的72名成人和78名儿童和青少年进行研究，比较小剂量维生素D（400 IU/日）和大剂量维生素D（儿童2000 IU/日; 成人4000 IU/日）对上述患者骨密度的影响。
Thirty-four percent of the adults were in the deficient range and 46% were in the insufficient range of vitamin D levels at baseline, the authors report, and 18% of children were in the deficient range and 44% in the insufficient range.
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作者:admin@医学,生命科学 2011-04-20 05:14
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