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【商业翻译】Grape seed seems to stem cancer cells（生命
Mice fed the grape seed were 44 percent less likely to have their colorectal tumors grow to an advanced stage, said Rajesh Agarwal, professor of pharmacy at the University of Colorado at Denver and Health Sciences Center.
The substance worked just as well on cell cultures in the lab, according to the study published this week in Clinical Cancer Research.
Grape seed somehow increases the presence of an important protein, Cip1/p21, that freezes the rapid cancer cell cycle and can even push the cancer cell to self-destruct.
"We are not suggesting that people run out and buy and use grape seed extract," Agarwal said. "That could be dangerous, since so little is known about doses and side effects."
Scientists have known that the skin and seeds of grapes are a rich source of proanthocyanidins, an antioxidant that removes harmful free oxygen radicals from cells.
Agarwal and his colleagues earlier were the first to demonstrate the usefulness of grape seed in stemming other cancers.
Grape juice and red wine also are known to be heart-healthy, but in moderation, of course.
Agarwal exposed two different human colon carcinoma cells to the grape seed extract. He found that the benefits kept increasing over time and with bigger doses.
The number of live cells went down by 92 percent in one cell line that got the highest dosage over the longest time, which was two days.
Delving deeper, the researchers found that the longer the grape seed was used, the more cancer cells were arrested before they actively duplicated their DNA. DNA duplication has to happen before cells can multiply in numbers.
Colorectal cancer is the second deadliest cancer, after lung cancer, and kills about 52,000 Americans each year. 坐个沙发. 呵呵. 认领了. 葡萄籽可抑制癌细胞
《临床肿瘤研究》本周报道，葡萄籽的某种成份可以抑制结肠直肠癌。这是由科罗拉多大学-丹佛健康科学中心发现的。
葡萄皮和葡萄籽均富含抗氧化剂原青花素，它可以去除细胞内有害的氧自由基。 因此，中心药理学教授Rajesh Agarwal和同事对葡萄籽功效进行研究，并最先报道了葡萄籽抑制其它癌症功效。
在本研究中，实验人员分别进行了动物实验和细胞培养实验。动物实验表明，喂养葡萄籽的老鼠其结肠直肠癌恶化率降低了44%；而细胞实验也得到了相似的结果。在两种结肠直肠癌细胞株中分别加入葡萄籽提取物，发现随着剂量增加和作用时间延长，细胞抑制效果增强。在最大剂量作用两天后，其中一个细胞株活细胞数减少92％。
对其机制研究表明，葡萄籽可使Cip1/p21蛋白增加，从而阻滞癌细胞周期，甚至使癌细胞死亡。
最后研究人员强调，因为有关葡萄籽剂量和副作用的资料还极少，也不能肯定是否有危险，因此不鼓励大家都出去购买或者食用葡萄籽提取物。 稿件已经采用，稿酬见：http://www.dxy.cn/bbs/post/view?bid=116&id=6908794&sty=1&tpg=1&age=0
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作者:admin@医学,生命科学 2010-12-06 05:11
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