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【Thyroid】MMP-2和TIMP-2的表达在甲状腺髓样癌中的
Expression of Matrix Metalloproteinase 2 (MMP-2)and Tissue Inhibitor of Metalloproteinase 2 (TIMP-2)in Medullary Thyroid Carcinoma: Prognostic Implications
Beatriz G. Cavalheiro,1 Consuelo Rodrigues Junqueira,2 and Lenine G. Branda˜o2
Background: Metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinase 2 (TIMP-2) participate in the degeneration of the extracellular matrix and are associated with carcinogenesis. MMP-2 is one of the main metalloproteinases active in neoplasia and is a marker of the malignant phenotype. Since the biological behavior of medullary thyroid carcinoma (MTC) varies widely, the present study was undertaken to determine if there is a correlation between the clinical evolution of MTC and the immunohistochemically detected expression of these enzymes in thyroid surgical specimens containing MTC. If so, their expression would be a novel indicator of the prognosis of MTC.
Methods: Thirty-seven patients with MTC who had undergone thyroid surgery were followed for an average of 73 months. Immunohistochemical staining for metalloproteinase-related enzymes was performed in surgical paraffin blocks. The clinical status of the patients after surgery and at the end of the study period was characterized to determine correlations between these and the immunohistochemical markers. A value of p < 0.05 was considered statistically significant.
Results: At the end of the study period, 15 patients (40.5%) were alive and without evidence of MTC, 17 (45.9%) had persistent MTC, and 5 (13.5%) had a relapse of their neoplasia. Four patients (10.8%) died during the course of the study. There was a significant correlation ( p¼0.0005) between the immunohistochemical staining for MMP-2 and the clinical condition of the patients at the end of the study period, and a correlation between the state of apparent cure compared to persistence of MTC after thyroid surgery ( p¼0.0207). No significant correlations were observed between either TIMP-2 expression or immune marking of metastatic lymph nodes and the clinical variables studied.
Conclusion: Immunohistochemical expression of MMP-2 in thyroid surgical specimens from patients with MTC is a novel indicator of the prognosis of this cancer. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Expression of Matrix Metalloproteinase 2 (MMP-2)and Tissue Inhibitor of Metalloproteinase 2 (TIMP-2)in Medullary Thyroid Carcinoma: Prognostic Implications
基质金属蛋白酶2（MMP-2）及其组织抑制剂TIMP-2在甲状髓样腺癌中的表达情况及预后意义
Beatriz G. Cavalheiro,Consuelo Rodrigues Junqueira,Lenine G. Brandao
Background: Metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinase 2 (TIMP-2) participate in the degeneration of the extracellular matrix and are associated with carcinogenesis. MMP-2 is one of the main metalloproteinases active in neoplasia and is a marker of the malignant phenotype. Since the biological behavior of medullary thyroid carcinoma (MTC) varies widely, the present study was undertaken to determine if there is a correlation between the clinical evolution of MTC and the immunohistochemically detected expression of these enzymes in thyroid surgical specimens containing MTC. If so, their expression would be a novel indicator of the prognosis of MTC.
背景：MMP-2和TIMP-2通过降解细胞外基质参与肿瘤的发生。MMP-2是肿瘤形成中的一种主要金属蛋白酶，可做为恶性表型的标记物。鉴于甲状腺髓样癌（MTC）的生物学行为有很多差异，我们用免疫组化法检测这些蛋白在MTC中的表达情况并与临床进展情况进行比较。如果与预后相关，那么这些蛋白可以做为新的预后指标。
Methods: Thirty-seven patients with MTC who had undergone thyroid surgery were followed for an average of 73 months. Immunohistochemical staining for metalloproteinase-related enzymes was performed in surgical paraffin blocks. The clinical status of the patients after surgery and at the end of the study period was characterized to determine correlations between these and the immunohistochemical markers. A value of p was considered statistically significant.
方法：对行手术切除且证实为MTC的77例患者进行平均为73个月的随访。用石蜡块对蛋白激酶进行免疫组化染色。记录患者术后及随访结束时的情况，用以与免疫组化标记物进行分析。P< 0.05被人为有统计学意义 。
Results: At the end of the study period, 15 patients (40.5%) were alive and without evidence of MTC, 17 (45.9%) had persistent MTC, and 5 (13.5%) had a relapse of their neoplasia. Four patients (10.8%) died during the course of the study. There was a significant correlation ( p¼ between the immunohistochemical staining for MMP-2 and the clinical condition of the patients at the end of the study period, and a correlation between the state of apparent cure compared to persistence of MTC after thyroid surgery ( p¼0.0207). No significant correlations were observed between either TIMP-2 expression or immune marking of metastatic lymph nodes and the clinical variables studied.
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作者:admin@医学,生命科学 2010-11-29 17:13
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