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【medical-news】肥胖与前列腺癌复发有关
肥胖与前列腺癌复发有关
Fri Aug 21, 11:48 pm ET
FRIDAY, Aug. 21 (HealthDay News) -- Obesity increases the risk of prostate cancer recurrence in both black and white men, says a U.S. study that challenges previous research suggesting obesity may be more significant for black men.
"Not so. Obesity leads to worse cancer in both groups," study senior author Dr. Stephen Freedland, an associate professor of urology and pathology at the Duke University Medical Center Prostate Center, said in a news release from the school.
Freedland and study author Dr. Jayakrishnan Jayachandran, a urology oncology fellow, examined the medical records of 1,415 prostate cancer patients who had undergone a radical prostatectomy. They found that race had no influence on the relationship between obesity and the aggressiveness of the cancer.
"We found that higher BMI [body-mass index] was associated with significantly increased risk of cancer recurrence for both blacks and whites," Jayachandran said in the news release.
The reason why obesity increases the risk of prostate cancer recurrence isn't clear, but altered hormone levels might play a role.
"Obesity is associated with more estrogen and less testosterone, and it may be that lower testosterone promotes more aggressive tumors as recent studies have suggested," Jayachandran said.
Other obesity-related changes in the production of hormones, such as insulin, insulin-like growth factor or leptin, may also be involved in the development of more aggressive prostate cancer.
"This is something we simply do not understand, but we are actively studying all of these factors," Jayachandran said.
The study appears in the current issue of Cancer.
http://news.yahoo.com/s/hsn/20090822/hl_hsn/obesitytiedtoprostatecancerrecurrence Obesity Tied to Prostate Cancer Recurrence
肥胖与前列腺癌复发有关
FRIDAY, Aug. 21 (HealthDay News) -- Obesity increases the risk of prostate cancer recurrence in both black and white men, says a U.S. study that challenges previous research suggesting obesity may be more significant for black men.
8月21日，周五（健康日报新闻）----一美国研究机构指出，肥胖症增加黑人和白人男性前列腺癌的复发风险，该研究机构意在挑战此前的研究提出的肥胖可能有益于黑人男性。
"Not so. Obesity leads to worse cancer in both groups," study senior author Dr. Stephen Freedland, an associate professor of urology and pathology at the Duke University Medical Center Prostate Center, said in a news release from the school.
Duke大学前列腺中心泌尿与病理部副教授，首席专家Stephen Freedland在学校新闻发布会上说：“两对照组中肥胖可导致较恶性的肿瘤的发生”。
Freedland and study author Dr. Jayakrishnan Jayachandran, a urology oncology fellow, examined the medical records of 1,415 prostate cancer patients who had undergone a radical prostatectomy. They found that race had no influence on the relationship between obesity and the aggressiveness of the cancer.
Freedland与研究作者，泌尿肿瘤研究员Jayakrishnan博士对1415例接受过前列腺癌根治术的患者病历进行了评估。他们发现人种对肥胖和肿瘤侵袭性相关性没有任何影响。
"We found that higher BMI [body-mass index] was associated with significantly increased risk of cancer recurrence for both blacks and whites," Jayachandran said in the news release.The reason why obesity increases the risk of prostate cancer recurrence isn't clear, but altered hormone levels might play a role.
Jayachandran在新闻发布会上说：“我们发现无论黑人或白人，较高的BMI(体重指数)与肿瘤复发风险增高之间有明显相关性”，至于肥胖为什么能增加前列腺癌复发的风险的原因尚不清楚，但是，改变体内激素水平可能起到一定的作用。
"Obesity is associated with more estrogen and less testosterone, and it may be that lower testosterone promotes more aggressive tumors as recent studies have suggested," Jayachandran said.
“肥胖与雌激素水平升高，睾酮水平降低有关，而且最近的研究显示低水平的睾酮更增加肿瘤的侵袭性” Jayachandran说。
Other obesity-related changes in the production of hormones, such as insulin, insulin-like growth factor or leptin, may also be involved in the development of more aggressive prostate cancer.
其他肥胖相关因素影响激素的合成，例如胰岛素，胰岛素样生长因子或瘦素，可能也参与前列腺癌侵袭性形成过程。
"This is something we simply do not understand, but we are actively studying all of these factors," Jayachandran said.
“这是我们大家不完全明白的机理，但我们可以主动地研究所有相关因素，” Jayachandran 说。
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作者:admin@医学,生命科学 2010-10-04 05:11
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