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【medical-news】年轻女性卵巢癌存活率高于老年人
Tue Nov 7, 2006 7:27 PM GMT
LONDON (Reuters) - Younger women with ovarian cancer have better survival rates than older patients, even if they have surgery to conserve their fertility, scientists said on Tuesday.
Ovarian cancer is known as the silent killer because it is often not detected until the illness is in an advanced stage and more difficult to treat.
But an American study showed that 59 percent of women diagnosed between the ages of 30-60 were still alive five years later, compared to only 35 percent of older women with the illness.
Ovarian cancer is rare in women under 30 but the 5-year survival rate for that age group was 79 percent.
"We found that younger patients have a better survival..," said Dr John Chan of Stanford University in California, in the British Journal of Cancer.
Although the improved survival of young women could be due in part to an earlier diagnosis and a lower grade of tumor, Chan and his team believe there may be other underlying, unknown factors linked to the improved prognosis.
The researchers also found no significant difference in the survival of women of child-bearing age who had been treated with surgery to conserve their fertility and those who had their wombs removed.
"Our results suggest that more pre-menopausal women diagnosed with ovarian cancer can be considered for fertility-sparing surgery," said Chan.
"Also, given the overall encouraging survival rates in this age group, we can potentially make a significant impact on the outcomes of these young women with novel strategies," he added.
About 190,000 new cases of ovarian cancer occur worldwide each year and 114,000 women die of the illness. The highest rates are reported in Scandinavia, Eastern Europe, the United States and Canada, according to the International Agency for Research on Cancer (IARC) in Lyon, France.
A family history of the illness is the most important risk factor and occurs in 5-10 percent of cases. The illness is influenced by hormones. Early puberty, late menopause, a history of breast cancer and not having children may increase the odds of developing it.
Chan's findings are based on an analysis of the medical history of 28,000 American women who had been diagnosed with ovarian cancer between 1988 and 2001.
The scientists called for more research into the potential biological and molecular differences that could account for the disparity in survival rates among the age groups.
http://today.reuters.co.uk/news/articlenews.aspx?type=healthNews&storyID=2006-11-07T192733Z_01_L06474461_RTRIDST_0_HEALTH-CANCER-OVARY-DC.XML&WTmodLoc=SciHealth-C4-Health-3 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Younger women survive ovarian cancer better
年轻女性卵巢癌存活率高于老年人
Tue Nov 7, 2006 7:27 PM GMT
LONDON (Reuters) - Younger women with ovarian cancer have better survival rates than older patients, even if they have surgery to conserve their fertility, scientists said on Tuesday.
伦敦（路透社）-本周二有科学家表示，年轻的卵巢癌患者即使接受了保留生育能力手术，她们的存活率仍高于老年患者。
Ovarian cancer is known as the silent killer because it is often not detected until the illness is in an advanced stage and more difficult to treat.
卵巢癌是公认的沉默杀手，因为卵巢癌的发展较为隐匿，往往到了晚期才被发现，增加了治疗的难度。
But an American study showed that 59 percent of women diagnosed between the ages of 30-60 were still alive five years later, compared to only 35 percent of older women with the illness.
但是，美国的一项研究发现， 30-60岁的卵巢癌患者的5年生存率达59%，而老年患者的5年生存率仅为25%。
Ovarian cancer is rare in women under 30 but the 5-year survival rate for that age group was 79 percent.
卵巢癌鲜见于30岁以下的女性，但这一年龄段患者的5年存活率高达79%。
"We found that younger patients have a better survival..," said Dr John Chan of Stanford University in California, in the British Journal of Cancer.
加利福尼亚斯坦福大学的陈约翰博士在《英国肿瘤杂志》上表示，年轻的卵巢癌患者的存活率较高。
Although the improved survival of young women could be due in part to an earlier diagnosis and a lower grade of tumor, Chan and his team believe there may be other underlying, unknown factors linked to the improved prognosis.
年轻患者存活率提高部分得益于早诊断以及肿瘤的病理分级低，尽管如此，陈博士等人认为仍存在着其他潜在的而未被发现的因素使卵巢癌的预后得以改善。
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作者:admin@医学,生命科学 2010-10-02 17:11
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