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【文摘发布】肝移植后细菌移位:传统静脉旁路转
Author:Abdala E, Baia CE, Mies S, Massarollo PC, de Paula Cavalheiro N, Baia VR, Inacio CA, Sef HC, Barone AA.
Source:Liver Transpl. 2007 Apr;13(4):488-96.
IF:4.447(2005)
The aim of this study was to evaluate the bacterial translocation in liver transplantation (LT), comparing the conventional and the piggyback methods. A total of 32 patients were randomized into the 2 groups. Samples of blood were collected from the radial artery, portal vein (PV) and hepatic vein (HV), in up to 120 minutes postreperfusion. The samples were sent for endotoxin level, as well as samples up to 2 minutes post-perfusion were sent to culture. Hepatic artery and PV blood flows were measured at postreperfusion collection times. The results analyzed were: endotoxin concentration, its quantity, and hepatic clearance. The statistical treatment consisted of analyzing each group's mean profile. The analysis for endotoxin concentration in the radial artery was the deviation related to presurgery measure, and in the PV the deviation related to preclamping (PC) measure. The overall mean level of endotoxin concentration was 0.99 EU/mL in the artery, 1.30 EU/mL in the PV, and 1.22 EU/mL in the HV. The deviation was significant in the portal (P = 0.0031), but not in the artery samples (P = 0.2092). We detected a significant quantity of endotoxin in the artery and in the portal and the HVs (P < 0.001). There was no difference between the 2 groups and no hepatic clearance of endotoxin was detected either (P = 0.1515). All the cultures were negative. In conclusion, the study detected a significant translocation of endotoxin, but not of bacteria. The study also detected the absence of endotoxin hepatic clearance in both the piggyback and the conventional methods without any difference between them. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Title:Bacterial translocation during liver transplantation: A randomized trial comparing conventional with venovenous bypass vs. piggyback methods.
题目：肝移植后细菌移位: 应用静脉转流传统肝移植与背驮式肝移植间的随机对比试验
Author:Abdala E, Baia CE, Mies S, Massarollo PC, de Paula Cavalheiro N, Baia VR, Inacio CA, Sef HC, Barone AA.
作者：Abdala E, Baia CE, Mies S, Massarollo PC, de Paula Cavalheiro N, Baia VR, Inacio CA, Sef HC, Barone AA.
Source:Liver Transpl. 2007 Apr;13(4):488-96.
来源：Liver Transpl. 2007 Apr;13(4):488-96.
IF:4.447(2005)
影响因子：4.447(2005)
The aim of this study was to evaluate the bacterial translocation in liver transplantation (LT), comparing the conventional and the piggyback methods.
这项研究的目的是对比传统肝移植和背驮式肝移植之间肝移植后的细菌移位。
A total of 32 patients were randomized into the 2 groups. Samples of blood were collected from the radial artery, portal vein (PV) and hepatic vein (HV), in up to 120 minutes postreperfusion. The samples were sent for endotoxin level, as well as samples up to 2 minutes post-perfusion were sent to culture. Hepatic artery and PV blood flows were measured at post reperfusion collection times.
总共32名患者被随机分为两组。再灌注后120分钟后从桡动脉、门静脉和肝静脉采血液样本。标本被用来检测内毒素水平，灌注后2分钟的标本用来进行培养。在留取再灌注后的标本时测量肝动脉和门静脉的血流。
The results analyzed were: endotoxin concentration, its quantity, and hepatic clearance. The statistical treatment consisted of analyzing each group's mean profile. The analysis for endotoxin concentration in the radial artery was the deviation related to presurgery measure, and in the PV the deviation related to preclamping (PC) measure. The overall mean level of endotoxin concentration was 0.99 EU/mL in the artery, 1.30 EU/mL in the PV, and 1.22 EU/mL in the HV. The deviation was significant in the portal (P = 0.0031), but not in the artery samples (P = 0.2092). We detected a significant quantity of endotoxin in the artery and in the portal and the HVs (P < 0.001). There was no difference between the 2 groups and no hepatic clearance of endotoxin was detected either (P = 0.1515). All the cultures were negative.
分析的结果包括内毒素浓度，内毒素总量和肝脏清除率。统计学处理包括分析每一组的平均分布。对内毒素浓度的分析是在桡动脉内的偏差与术前处理有关，而对门静脉内偏差与预钳夹有关。所有的平均内毒素水平在动脉内为0.99 EU/mL，在门静脉内为1.30 EU/mL，在肝静脉内为1.22 EU/mL。在门静脉内标本的差异是有意义的(P = 0.0031)，但在动脉标本内没意义(P = 0.2092)。我们在动脉和门静脉、肝静脉内检出了大量的内毒素(P < 0.001)。这两组和没有经肝脏清除内毒素标本之间也没有差异(P = 0.1515)。所有的培养结果都是阴性的。
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作者:admin@医学,生命科学 2010-10-01 11:08
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