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【medical-news】乳腺癌死亡率随体重指数而增加
NEW YORK (Reuters Health) - A higher body mass index (BMI) is associated with lower survival rates in women with breast cancer, according to a report in the July 10th issue of the Journal of Clinical Oncology.
"We have found strong evidence that high BMI and a recent pregnancy are associated with a poorer prognosis after a diagnosis of breast cancer," Dr. Gillian C. Barnett told Reuters Health. "Our study suggests that advice on weight loss should be given to all obese patients with breast cancer."
Dr. Barnett from Addenbrooke's Hospital, Cambridge, UK and colleagues investigated the impact of established risk factors for incident breast cancer on overall survival after a diagnosis of breast cancer, using data from the Studies of Epidemiology and Risk Factors in Cancer Heredity.
Women with the highest BMIs were 52 percent more likely to die than women with the lowest BMIs, the investigators report. BMI is the ratio of weight to height, which is often used to see if a patient's weight is outside normal parameters.
"The Women's Interventional Nutritional Study reported improved event-free survival in women randomly assigned to a reduced fat diet (associated with weight loss)," Barnett pointed out. "Further definitive clinical weight loss intervention trials in breast cancer populations are required to further clarify the relationship between breast cancer mortality and BMI."
Survival was also significantly worse in women who had four or more full-term pregnancies and in women whose last pregnancy was more recent, the report indicates.
In contrast, the team found that prognosis improved with recent alcohol consumption, with light to moderate drinking reducing the risk of dying by 22 percent.
"The association between alcohol consumption and improved survival is surprising," Barnett commented. "The results of several other studies have not shown such an association."
SOURCE: Journal of Clinical Oncology, July 10, 2008.
http://www.reuters.com/article/healthNews/idUSREE58069320080725 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。
译文如下：
Breast cancer mortality increases with body mass index
乳腺癌死亡率随体重指数而增加
NEW YORK (Reuters Health) - A higher body mass index (BMI) is associated with lower survival rates in women with breast cancer, according to a report in the July 10th issue of the Journal of Clinical Oncology.
纽约（路透社 健康版）---临床肿瘤杂志7月份第十期的一篇报导指出：较高的体重指数（BMI）的乳腺癌妇女有较低的生存率。
"We have found strong evidence that high BMI and a recent pregnancy are associated with a poorer prognosis after a diagnosis of breast cancer," Dr. Gillian C. Barnett told Reuters Health. "Our study suggests that advice on weight loss should be given to all obese patients with breast cancer."
Dr. Gillian C. Barnett告诉路透社健康版记者：“我们已经找到关于高体重指数与近期受孕预示着乳腺癌有不良预后的强有力的证，我们的研究表明所有肥胖的乳腺癌患者应该接受减肥的忠告。”
Dr. Barnett from Addenbrooke's Hospital, Cambridge, UK and colleagues investigated the impact of established risk factors for incident breast cancer on overall survival after a diagnosis of breast cancer, using data from the Studies of Epidemiology and Risk Factors in Cancer Heredity.
来自英国剑桥的Addenbrooke's医院Dr. Barnett和他的同事调查了乳腺癌已经明确的危险因素对总生存率的影响，分析的数据来自关于肿瘤遗传的流行病学与危险因素研究。
Women with the highest BMIs were 52 percent more likely to die than women with the lowest BMIs, the investigators report. BMI is the ratio of weight to height, which is often used to see if a patient's weight is outside normal parameters.
研究者指出：较高体重指数女性患者的死亡率要比那些较低体重指数的女性患者高出52%。体重指数是指体重与身高的比值，通常用来评估患者的体重是否超出正常范围。
"The Women's Interventional Nutritional Study reported improved event-free survival in women randomly assigned to a reduced fat diet (associated with weight loss)," Barnett pointed out. "Further definitive clinical weight loss intervention trials in breast cancer populations are required to further clarify the relationship between breast cancer mortality and BMI."
Barnett还指出：“一项关于妇女干预营养研究报导了随机给定低脂饮食的妇女（伴随体重的减轻）有较高的生存率。接下来的关于对乳腺癌人群采取限定减轻体重的临床干预试验值得进一步阐明乳腺癌死亡率与体重指数的关系”。
Survival was also significantly worse in women who had four or more full-term pregnancies and in women whose last pregnancy was more recent, the report indicates.
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作者:admin@医学,生命科学 2011-07-10 17:31
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