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【medical-news】廉价药物双水杨酸酯有可能预防糖
Released: Mon 28-Jan-2008, 00:00 ET
Newswise — An anti-inflammatory drug similar to aspirin may provide an inexpensive means of treating and/or reducing the risk for diabetes in obese young adults by reducing glycemia and lowering inflammation, a study being published in the February issue of Diabetes Care finds.
While researchers have long been aware that high doses of aspirin could reduce blood glucose levels, they have neither understood the mechanisms behind this effect nor been willing to tolerate the risk for stomach bleeding associated with this treatment. However, recent breakthroughs in our understanding of why weight gain is unhealthy point an incriminating finger at inflammation, and suggest that anti-inflammatory treatment strategies might have benefits.
Salsalate – a nonsteroidal, anti-inflammatory medication similar to aspirin that does not cause bleeding – has been used for decades to reduce the pain of rheumatoid arthritis. This double-masked, placebo-controlled study found that salsalate substantially reduced glycemia as well as inflammation in obese, young adults, thereby likely reducing the risk of developing type 2 diabetes and heart disease.
“People who are overweight or obese are at high risk for developing type 2 diabetes,” said lead researcher Dr. Allison B. Goldfine, Assistant Professor at Harvard Medical School and Research Investigator at the Joslin Diabetes Center. “We know they can reduce that risk by losing weight and increasing physical activity. But many people aren’t good at maintaining those types of lifestyle changes over the long-term. Those people can be helped through pharmaceutical interventions. Our study was the first to look at the metabolic changes that occur when you give salsalate to obese people who have not yet developed diabetes. And we’re really encouraged by what we found.”
Specifically, the study found that people who took 4 grams per day of salsalate reduced fasting glucose levels by 13 percent and C-reactive protein concentrations (a marker of inflammation) by 34 percent. Previous studies have implicated inflammation in the development of type 2 diabetes and heart disease.
The encouraging results from this small population study have prompted the National Institutes of Health to fund a larger, follow-up study that will look at safety and efficacy of targeting inflammation using salsalate in the treatment of type 2 diabetes. The study is currently ongoing at multiple sites across the country.
For more information about the study, please visit http://www.tinsalt2d.org.
Diabetes Care, published by the American Diabetes Association, is the leading peer-reviewed journal of clinical research into the nation’s fifth leading cause of death by disease. Diabetes also is a leading cause of heart disease and stroke, as well as the leading cause of adult blindness, kidney failure, and non-traumatic amputations. For more information about diabetes, visit the American Diabetes Association Web site www.diabetes.org or call 1-800-DIABETES (1-800-342-2383). Salsalate May Help Reduce Risk for Diabetes, Heart Disease
双水杨酸酯有望降低糖尿病、心脏病的罹患风险
Released: Mon 28-Jan-2008, 00:00 ET
Newswise — An anti-inflammatory drug similar to aspirin may provide an inexpensive means of treating and/or reducing the risk for diabetes in obese young adults by reducing glycemia and lowering inflammation, a study being published in the February issue of Diabetes Care finds.
Newswise——一个和阿司匹林类似的抗炎药物能通过降低血糖、减少炎症而有望成为治疗青壮年肥胖人群患糖尿病或降低其罹患风险的一种廉价药物。该研究结果将发表在2月出版的《糖尿病治疗》（Diabetes Care）杂志上。
While researchers have long been aware that high doses of aspirin could reduce blood glucose levels, they have neither understood the mechanisms behind this effect nor been willing to tolerate the risk for stomach bleeding associated with this treatment. However, recent breakthroughs in our understanding of why weight gain is unhealthy point an incriminating finger at inflammation, and suggest that anti-inflammatory treatment strategies might have benefits.
虽然早有研究表明大剂量阿司匹林能降低血糖水平，但是背后的机制尚不清楚，也没人愿意担当随治疗而来的胃出血风险。不从过最近有关炎症和肥胖因果关系的突破性研究结果来看，抗炎治疗可能大有裨益。
Salsalate – a nonsteroidal, anti-inflammatory medication similar to aspirin that does not cause bleeding – has been used for decades to reduce the pain of rheumatoid arthritis. This double-masked, placebo-controlled study found that salsalate substantially reduced glycemia as well as inflammation in obese, young adults, thereby likely reducing the risk of developing type 2 diabetes and heart disease.
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作者:admin@医学,生命科学 2011-06-28 18:00
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