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medicalnewstoday编译－移植的猪胰岛细胞在一糖尿病
今天，活细胞技术有限公司报道被囊的猪胰岛在一个Ι型糖尿病男病人身上长期存活。在病人的腹部内待了近九年后重新获得这些细胞。
在1996年，一个患有Ι型糖尿病的40岁男子接收了该公司DiaB细胞早期原型的移植,作为一个已批准的临床试验的一部分。Ι型糖尿病人不可能由自身提供足量的胰岛素。猪胰岛的移植意在释放胰岛素和恢复对血糖水平的控制。
猪胰岛置于藻酸盐胶囊里保护他们免受免疫排斥，而且在这移植中未使用任何免疫抑制剂。
今年5月，在日内瓦胰腺和胰岛移植国际会议上介绍了糖尿病病人身上胰岛移植存活九年。
既然移植的胰岛能代替胰腺分泌胰岛素功能，这正是Ι型糖尿个体所缺的，医药从事者和患者都对猪胰岛移植表现出极大兴趣。
适合移植的人类胰岛的获取极度有限，致使猪胰岛的治疗作用成为重要的替代品，尤其是猪胰岛素与人胰岛素一致，并在上个世纪早期已在临床应用。关于 DiaB细胞（糖尿病B细胞）：DiaB细胞采用微体凝胶包裹，保护移植的活体胰岛免受受者免疫系统的破坏。胰岛是胰腺特殊的细胞群，血糖水平增高，它就分泌和释放胰岛素入血，在餐后经常发生。
增高的葡萄糖刺激胰岛产生胰岛素，胰岛素刺激机体组织把葡萄糖作为能源消耗掉，引起血糖水平下降。当血糖恢复到正常水平，胰岛刺激分泌的胰岛素自动停止分泌。
http://www.medicalnewstoday.com/medicalnews.php?newsid=24059
Nine-year survival of transplanted pig islet cells in a diabetic patient
09 May 2005
Living Cell Technologies Ltd today reported the long-term survival of encapsulated pig islets in a man with type 1 diabetes. The cells were retrieved after being in the patient's abdomen for almost nine years.
A 40 year old man with Type 1 diabetes received a transplant of an early prototype of LCT's DiaBCell in 1996, as part of an approved clinical trial. Type 1 diabetics are not able to produce sufficient insulin of their own. The pig islet transplants were intended to release insulin and restore control of blood glucose levels.
The pig islets were prepared in an alginate capsule to protect them from immune rejection and no immune suppressive drugs were needed for this transplant.
The nine-year survival of transplanted islets in the diabetic patient has been accepted for presentation at the International Pancreas and Islet Transplant meeting in Geneva in May this year.
Pig islet transplantation is of particular interest to medical practitioners and patients since implanted islets can replace the insulin-producing function of the pancreas, which is lost in individuals with type 1 diabetes.
The extremely limited availability of suitable human islets for transplantation makes the therapeutic use of pig islets an important alternative, particularly because pig insulin is almost identical to human insulin and has been used clinically since the early part of last century. About DiaBCell: DiaBCell uses its micro-gel coating to protect the transplanted living islets from damage by the recipient's immune system. Islets are the specialised cell groups in the pancreas, which produce and secrete insulin into the blood in response to increased glucose levels, such as occurs after a meal.
The increased glucose stimulates the islets to produce insulin, the insulin signals the body's tissues to take up glucose as a source of energy, causing the blood glucose levels to decrease. When blood glucose returns to normal levels, the stimulated secretion of insulin by the islet automatically stops. 人体移植最大的难关是排斥反应。
上海医学院进行一例自体脑细胞植入手术。由意外受伤导致竹筷插入小脑，手术带出部分脑细胞。脑细胞经人工培养成活，再次植入使受损功能得到恢复。
参看这篇文章，可以想见的未来人类的生存机率会有更大的提高！ [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-04-19 05:14
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