主页 > 医学动态 >
肌钙蛋白T 可判断心肌梗死面积
4 December 2006
Levels of cardiac troponin T (cTnT) following ST/non-ST segment elevation myocardial infarction (STEMI/NSTEMI) provide a reliable estimate of the infarct mass, study findings indicate.
Researchers found that estimates of infarct size based on cTnT levels at 96 hours after STEMI/NSTEMI onset showed significant correlation with values derived from contrast-enhanced magnetic resonance imaging (CE-MRI).
CE-MRI and nuclear imaging techniques are non-invasive methods that provide an accurate measure of myocardial infarct size, but, due to limited availability and high costs, serologic tests are frequently used as an alternative, explain Evangelos Giannitsis (Universitätsklinikum Heidelberg, Germany) and colleagues.
The researchers compared measurements of infarct size obtained by CE-MRI 4 days after STEMI/NSTEMI with cTnT measurements at 96 hours after STEMI/NSTEMI onset in 23 STEMI and 21 NSTEMI patients.
CE-MRI gave an absolute mean infarct size of 16.2 g, with a mean ejection fraction of 58% and mean stroke volume of 84 ml, the team reports in the Journal of the American College of Cardiology.
Infarct size and median cTNT values were greater in STEMI than NSTEMI patients, at 29.3 g versus 8.8 g and 1.88 µg/l versus 0.83 µg/l, respectively (both p<0.02).
Linear regression analysis revealed excellent correlation between CE-MRI infarct mass and cTnT levels in the STEMI group (r=0.910) and moderate, although still significant, correlation in the NSTEMI group (r=0.575).
“A single 96-hour cTnT value provides an accurate estimate of absolute infarct mass in MI,” the authors say.
“The ability to quantify and the potential to distinguish effects of novel drug regimens on infarct size make cTnT attractive for routine practice and as a clinical end point,” they conclude.
J Am Coll Cardiol 2006; 48: 2192-2194
http://www.incirculation.net/NewsItem/Cardiac-troponin-T-a-marker-of-infarct-size-in-MI.aspx 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 Cardiac troponin T a marker of infarct size in MI
心肌肌钙蛋白T可作为心肌梗塞范围的一个标志
4 December 2006
2006年12月4日
Levels of cardiac troponin T (cTnT) following ST/non-ST segment elevation myocardial infarction (STEMI/NSTEMI) provide a reliable estimate of the infarct mass, study findings indicate.
研究发现心肌肌钙蛋白(cTnT)可进行可靠地预测ST段抬高的心肌梗死(STEMI)和ST段不抬高的心肌梗死(NSTEMI)的梗塞范围。
Researchers found that estimates of infarct size based on cTnT levels at 96 hours after STEMI/NSTEMI onset showed significant correlation with values derived from contrast-enhanced magnetic resonance imaging (CE-MRI).
研究人员发现STEMI/NSTEMI发作后96小时依据cTnT的水平来预测梗塞范围的结果与通过增强MRI得到的数据密切相关。
CE-MRI and nuclear imaging techniques are non-invasive methods that provide an accurate measure of myocardial infarct size, but, due to limited availability and high costs, serologic tests are frequently used as an alternative, explain Evangelos Giannitsis (Universitätsklinikum Heidelberg, Germany) and colleagues.
德国的Evangelos Giannitsis和他的同事们解释说，增强MRI和核显像技术是可提供心肌梗塞范围的准确、无创的方法，但是缺点是不普及和高费用，所以血清学检测是经常进行的一种替代方法。
The researchers compared measurements of infarct size obtained by CE-MRI 4 days after STEMI/NSTEMI with cTnT measurements at 96 hours after STEMI/NSTEMI onset in 23 STEMI and 21 NSTEMI patients.
研究人员对23名STEMI患者和21名NSTEMI患者进行了研究，比较了STEMI/NSTEMI四天后由增强MRI检测的梗塞范围数据和STEMI/NSTEMI发作后96小时的cTnT水平。
CE-MRI gave an absolute mean infarct size of 16.2 g, with a mean ejection fraction of 58% and mean stroke volume of 84 ml, the team reports in the Journal of the American College of Cardiology.
研究小组在“Journal of the American College of Cardiology”杂志上发表结果显示：增强MRI给出的平均梗塞大小为16.2g，平均射血分数是58%，平均每博输出量为84ml。
Infarct size and median cTNT values were greater in STEMI than NSTEMI patients, at 29.3 g versus 8.8 g and 1.88 µg/l versus 0.83 µg/l, respectively (both p<0.02).
STEMI患者比NSTEMI患者的梗塞范围和平均cTnT数值都比较大，梗塞范围分别为29.3g和8.8g，而平均cTnT分别为1.88 µg/l和0.83 µg/l（二者p<0.02）。
Linear regression analysis revealed excellent correlation between CE-MRI infarct mass and cTnT levels in the STEMI group (r=0.910) and moderate, although still significant, correlation in the NSTEMI group (r=0.575).
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-05-28 05:14
医学,生命科学网