主页 > 医学动态 >
【medical-news】皮层定位图有望实现阿尔茨海默病
By Will Boggs, MD
NEW YORK (Reuters Health) Oct 24 - Advanced 3-dimensional cortical mapping can distinguish between mild cognitive impairment (MCI) and mild Alzheimer disease (AD), according to a report in the October issue of the Archives of Neurology.
"AD pathology marches through the brain many years before we can diagnose it - which is unsettling," Dr. Liana G. Apostolova told Reuters Health. "These avant-garde neuroimaging advances deliver a promise that pre-clinical diagnosis of AD will soon be feasible."
Dr. Apostolova from the David Geffen School of Medicine, University of California at Los Angeles, and associates used 3-D cortical mapping to analyze structural MRI data for 24 patients with amnestic MCI and 25 patients with mild AD.
Patients with mild AD showed 10% to 15% greater gray matter atrophy in most of the cortex than did patients with amnestic MCI, the authors report.
Atrophy was more than 15% greater in the bilateral entorhinal, right more than left lateral temporal, right parietal cortex, and bilateral precuneus areas.
In both groups of patients, the researchers note, there was less cortical gray matter in the right hemisphere than in the left hemisphere.
"With several promising disease-modifying candidate compounds under development, being able to discern subtle structural cortical changes between mild AD and the immediately preceding cognitive state of amnestic MCI with anatomical precision raises hopes for our ability to show structural disease-modifying effects," the investigators say.
"At this point these analysis methods are largely a research tool, but we are hopeful in the near future to develop software techniques that could be useful in the clinic," Dr. Apostolova said. "Our new maps reveal the systems that change with the gradual descent to AD, and we hope to compare individual imaging findings to these maps to help understand future prognosis."
Arch Neurol 2007;64:1489-1495.
http://www.medscape.com/viewarticle/564808 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Cortical Mapping Shows Early Changes Associated With Alzheimer Disease By Will Boggs, MD
皮层定位图显示阿尔茨海默病的早期改变
NEW YORK (Reuters Health) Oct 24 - Advanced 3-dimensional cortical mapping can distinguish between mild cognitive impairment (MCI) and mild Alzheimer disease (AD), according to a report in the October issue of the Archives of Neurology.
根据在Archives of Neurology《神经病学纪要》十月刊上的报告，先进的三维皮层定位图可以识别早期认知功能障碍（MCI）与阿尔茨海默病（AD）的不同改变。NEW YORK (Reuters Health) Oct 24
"AD pathology marches through the brain many years before we can diagnose it - which is unsettling, 抱歉翻译晚了
标记部分想了很久还是翻不好
特别是那个长句不知怎么断，而且意思上也有点偏颇 请指教 With several promising disease-modifying candidate compounds under development, being able to discern subtle structural cortical changes between mild AD and the immediately preceding cognitive state of amnestic MCI with anatomical precision raises hopes for our ability to show structural disease-modifying effects," the investigators say
在几种有前景却发展不全面的可以改善疾病的候选因素中，应用解剖精度能够区分早期AD与早期遗忘型MCI在皮质细微结构上的变化这项技术为我们能够展明结构学对改善疾病的影响带来更大的希望。 [标签:content1][标签:content2]
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-05-23 05:11
医学,生命科学网