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【medical-news】1918年流感病毒聚合酶基因特征
Author: Taubenberger, JK; Reid, AH; Lourens, RM, et al.
Source: NATURE Volume: 437 Issue: 7060 Pages: 889-893 Published: OCT 6 2005
Times Cited: 202
The influenza A viral heterotrimeric polymerase complex (PA, PB1, PB2) is known to be involved in many aspects of viral replication and to interact with host factors(1), thereby having a role in host specificity(2,3). The polymerase protein sequences from the 1918 human influenza virus differ from avian consensus sequences at only a small number of amino acids, consistent with the hypothesis that they were derived from an avian source shortly before the pandemic. However, when compared to avian sequences, the nucleotide sequences of the 1918 polymerase genes have more synonymous differences than expected, suggesting evolutionary distance from known avian strains. Here we present sequence and phylogenetic analyses of the complete genome of the 1918 influenza virus(4-8), and propose that the 1918 virus was not a reassortant virus ( like those of the 1957 and 1968 pandemics(9,10)), but more likely an entirely avian-like virus that adapted to humans. These data support prior phylogenetic studies suggesting that the 1918 virus was derived from an avian source(11). A total of ten amino acid changes in the polymerase proteins consistently differentiate the 1918 and subsequent human influenza virus sequences from avian virus sequences. Notably, a number of the same changes have been found in recently circulating, highly pathogenic H5N1 viruses that have caused illness and death in humans and are feared to be the precursors of a new influenza pandemic. The sequence changes identified here may be important in the adaptation of influenza viruses to humans. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Title: Characterization of the 1918 influenza virus polymerase genes
1918流感病毒聚合酶基因的特征
The influenza A viral heterotrimeric polymerase complex (PA, PB1, PB2) is known to be involved in many aspects of viral replication and to interact with host factors(1), thereby having a role in host specificity(2,3).
甲型流感病毒的异源三聚聚合酶复合物蛋白（PA,PB1,PB2）在病毒复制过程中的各个发面起着作用，也是与宿主相互作用的因子，因此也体现出了宿主的特异性。
The polymerase protein sequences from the 1918 human influenza virus differ from avian consensus sequences at only a small number of amino acids, consistent with the hypothesis that they were derived from an avian source shortly before the pandemic.
1918人流感病毒聚合酶蛋白序列与禽流感病毒的只有少数几个氨基酸的差别，这也符合了人流感病毒在流行前起源于禽类的假说。
However, when compared to avian sequences, the nucleotide sequences of the 1918 polymerase genes have more synonymous differences than expected, suggesting evolutionary distance from known avian strains.
可是，进一步与禽流感病毒序列比较后发现，1918人流感病毒的核酸序列差异还是比想象的大，提示了距已知禽流感病毒的分子进化关系比较远。
Here we present sequence and phylogenetic analyses of the complete genome of the 1918 influenza virus(4-8), and propose that the 1918 virus was not a reassortant virus ( like those of the 1957 and 1968 pandemics(9,10)), but more likely an entirely avian-like virus that adapted to humans.
我们对1918流感病毒全序列进行序列及系统进化分析后发现，1918流感病毒类似1957及1968大流行的病毒，不是再造病毒。但是，更像一种嗜人的类禽流感病毒。
These data support prior phylogenetic studies suggesting that the 1918 virus was derived from an avian source(11).
这些数据都支持了先前的系统研究关于1918流感病毒来源于禽类的论断。
A total of ten amino acid changes in the polymerase proteins consistently differentiate the 1918 and subsequent human influenza virus sequences from avian virus sequences.
1918流感病毒及后来发生的人流感病毒与禽流感病毒之间的多聚酶蛋白序列只有10个氨基酸的差别。
Notably, a number of the same changes have been found in recently circulating, highly pathogenic H5N1 viruses that have caused illness and death in humans and are feared to be the precursors of a new influenza pandemic.
值得注意的是，新一轮循环发现了很多同样的变化，高致病性H5N1病毒能使人致病和死亡，可能是下一次流感大流行的前体。
The sequence changes identified here may be important in the adaptation of influenza viruses to humans.
这些序列变异可能在流感病毒对人类待易感性改变起着重要的作用。 编译
1918流感病毒聚合酶基因的特征
甲型流感病毒的异源三聚聚合酶复合物蛋白（PA,PB1,PB2）在病毒复制过程中的各个发面起着作用，也是与宿主相互作用的因子，因此也体现出了宿主的特异性。1918人流感病毒聚合酶蛋白序列与禽流感病毒的只有少数几个氨基酸的差别，这也符合了人流感病毒在流行前起源于禽类的假说。可是，进一步与禽流感病毒序列比较后发现，1918人流感病毒的核酸序列差异还是比想象的大，提示了距已知禽流感病毒的分子进化关系比较远。我们对1918流感病毒全序列进行序列及系统进化分析后发现，1918流感病毒类似1957及1968大流行的病毒，不是再造病毒。但是，更像一种嗜人的类禽流感病毒。这些数据都支持了先前的系统研究关于1918流感病毒来源于禽类的论断。1918流感病毒及后来发生的人流感病毒与禽流感病毒之间的多聚酶蛋白序列只有10个氨基酸的差别。值得注意的是，新一轮循环发现了很多同样的变化，高致病性H5N1病毒能使人致病和死亡，可能是下一次流感大流行的前体。这些序列变异可能在流感病毒对人类待易感性改变起着重要的作用。 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-05-02 05:11
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