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【编译】nature生命科学动态
原文:Magnaporthe grisea is the most destructive pathogen of rice worldwide and the principal model organism for elucidating the molecular basis of fungal disease of plants. Here, we report the draft sequence of the M. grisea genome. Analysis of the gene set provides an insight into the adaptations required by a fungus to cause disease. The genome encodes a large and diverse set of secreted proteins, including those defined by unusual carbohydrate-binding domains. This fungus also possesses an expanded family of G-protein-coupled receptors, several new virulence-associated genes and large suites of enzymes involved in secondary metabolism. Consistent with a role in fungal pathogenesis, the expression of several of these genes is upregulated during the early stages of infection-related development. The M. grisea genome has been subject to invasion and proliferation of active transposable elements, reflecting the clonal nature of this fungus imposed by widespread rice cultivation.
译文:世界上最主要的作物之一水稻的最具破坏性的病原体的基因组序列已经测定完成了。稻瘟病菌（Magnaporthe grisea）是第一种被测定的真菌性植物病原体基因组，由于水稻的基因组已经被测序，所以它为研究寄主与病原体之间的关系提供了一个独特的机会。本研究早期的发现包括一个家族的G-蛋白，与参与破坏寄主防卫系统的受体偶合在一起；一个对这种病原体有特效的杀菌剂的候选目标。该基因组在过去曾被其他基因元素入侵，很可能有助于在遇到新引进的有抗病能力的水稻品种时迅速发生演化。 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-04-26 17:14
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