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【bio-news】科学家发现男性不育“关键”
1 Jul, 2007 l 0043 hrs ISTlANI
WASHINGTON: Researchers at The Feinstein Institute for Medical Research have identified an immune substance in human semen that appears to determine the fertility of a man.
Dr Yousef Al-Abed says that the substance called macrophage migration inhibitory factor (MIF) is the key to helping sperm mature, which is necessary for its union with an egg. The findings, published in Molecular Medicine, attain significance as they may lead to a diagnostic test to determine fertility status.
During the study, the researchers collected semen samples from men three to five days after a period of sexual abstinence. While 68 men had problems conceiving, 27 were healthy controls. When the researcher were analysing the levels of MIF, they did not have any idea as to whether the samples came from infertile men or from healthy controls.
It was observed that the MIF levels in men with infertility problems were either too high or too low, while healthy controls had levels that were just right.
Upon adding MIF into petri dishes filled with healthy sperm, the researchers noted that their count had decreased, and motility impaired.
Dr Al-Abed also wonders whether MIF can work as a form of male contraceptive, if it has a role in infertility.
MIF is a key player of the immune system that has also been linked to many autoimmune and inflammatory diseases, such as diabetes and sepsis.
Dr Al-Abed has been trying to identify and design small molecules that would block the activities of MIF.
Past studies have found MIF plays a key role in sperm maturation. But it has also been linked to several autoimmune and inflammatory diseases, such as diabetes and sepsis, which is a systematic inflammatory response to infection.
Unusually high levels of macrophage migration inhibitory factor have also been found in individuals suffering from rheumatoid arthritis.
About 15% of couples attempting to get pregnant for the first time experience problems conceiving. About 40% of infertility problems are due to disorders in the male.
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Scientists find 'key' to man's infertility
1 Jul, 2007 l 0043 hrs ISTlANI
科学家发现男性不育关键
2007年7月1日 00：43 ISTlANI
WASHINGTON: Researchers at The Feinstein Institute for Medical Research have identified an immune substance in human semen that appears to determine the fertility of a man.
华盛顿消息：Feinstein医学研究部的研究人员鉴别出存在于人类精子中的一种免疫物质，它似乎决定着男性的生育力。
Dr Yousef Al-Abed says that the substance called macrophage migration inhibitory factor (MIF) is the key to helping sperm mature, which is necessary for its union with an egg. The findings, published in Molecular Medicine, attain significance as they may lead to a diagnostic test to determine fertility status.
Yousef Al-Abed博士称，这种名为巨噬细胞移动抑制因子（MIF）的物质是帮助精子成熟的关键，精子成熟是其与卵子结合的必须步骤。研究结果发表于《分子医学》杂志，它将引导开发诊断性试验方法，用于明确生育状态，具有重要意义。
During the study, the researchers collected semen samples from men three to five days after a period of sexual abstinence. While 68 men had problems conceiving, 27 were healthy controls. When the researcher were analysing the levels of MIF, they did not have any idea as to whether the samples came from infertile men or from healthy controls.
在此次研究中，研究人员收集了禁欲一段时间后3至5天内的男性精子样本。其中68例受孕障碍，27例为健康对照组。研究人员分析了MIF水平，他们完全不知道这些样本是来自不育男性还是健康对照者。
It was observed that the MIF levels in men with infertility problems were either too high or too low, while healthy controls had levels that were just right. 据观察，不育男性体内MIF水平或过高，或过低，而健康男性MIF水平正常。
Upon adding MIF into petri dishes filled with healthy sperm, the researchers noted that their count had decreased, and motility impaired.
在装满健康精子的培养皿里，加入MIF后，研究员们注意到精子数量减少，同时活力减弱。
Dr Al-Abed also wonders whether MIF can work as a form of male contraceptive, if it has a role in infertility.
Al-Abed博士设想，如果MIF与不育有关，那它是否可以用作男性避孕剂。
MIF is a key player of the immune system that has also been linked to many autoimmune and inflammatory diseases, such as diabetes and sepsis.
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作者:admin@医学,生命科学 2011-03-04 17:12
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