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【drug-news】Nuvelo 抗血栓新药临床效果不佳,Bay

Bayer Healthcare AG terminated its agreement with San Carlos-based Nuvelo Inc. to develop and sell the anti-blood clotting drug alfimeprase, but Nuvelo said it still will move forward with clinical trials.

Bayer, which paid $50 million when the deal was signed in January 2006, will pay Nuvelo (NASDAQ: NUVO - News) an additional $15 million within 30 days, Nuvelo said in a press release.

Bayer has the option to reacquire the right to develop and commercialize the drug outside the United States with an another $15 million payment.

The drug did not meet late-stage clinical trial markers for two trials treating blood clot disorders, the companies said in December, and a third study was put on hold.

But Nuvelo officials said the company will begin a phase 2 proof-of-concept trial with alfimeprase in the second half. Plus, a phase 3 trial, using a higher dosage, also will begin in the second half.

"We believe that a safer, more efficacious intra-arterial therapy can change the treatment paradigm for these patients and that a product candidate such as alfimeprase holds the potential to rapidly restore flow and expand the treatment window beyond the current three-hour timeframe," said Nuvelo Chairman and CEO Ted Love. [标签:content1][标签:content2]

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作者:admin@医学,生命科学    2011-02-25 05:11
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