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IBD May Double Risk of Serious Blood Clots, Study Finds
By Jennifer Warner
WebMD Health News
Reviewed by Laura J. Martin, MD
Feb. 22, 2011 -- Inflammatory bowel disease may more than double the risk of a serious blood clot in the legs or lungs, according to a new study.
Inflammatory bowel disease (IBD) is an umbrella term that includes a variety of intestinal disorders, such as Crohn’s disease and ulcerative colitis.
Researchers found that children and adults with IBD were more than twice as likely to develop a dangerous type of blood clot that develops in the leg, known as deep vein thrombosis (DVT), or lung, called pulmonary embolism (PE).
These types of blood clots affect about two out of every 1,000 people in developed countries each year, and the risk generally increases with age.
But in this study, researchers found the results showed the relative risk of blood clots associated with IBD was particularly high among young people.
In people aged 20 and younger, the relative risk of a pulmonary embolism was six times higher among people with inflammatory bowel disease, compared to similarly aged people without IBD.
A Visual Guide to Inflammatory Bowel Disease (IBD)
IBD Raises Clot Risk
The study compared the risk of pulmonary embolism and deep vein thrombosis in 49,799 Danish adults and children with IBD and more than 477,000 Danish people without IBD, who were followed from 1980 to 2007.
After accounting for other factors known to increase the risk of blood clots, such as a broken bone, cancer, surgery, or pregnancy, researchers found that the risk of pulmonary embolism and deep vein thrombosis was twice as high in people with IBD compared to people without IBD.
In a further analysis, researchers also took into account chronic medical conditions associated with an increased risk of blood clots, including heart disease, diabetes, congestive heart failure, and the use of hormone replacement therapy or antipsychotic drugs. They found that the risk of blood clots still remained up to 80% higher among people with IBD.
Researcher Michael Kappelman, MD, of the University of North Carolina at Chapel Hill and colleagues say the results confirm previous studies that have shown that IBD increases the risk of blood clots. In addition, they suggest that inflammatory bowel disease may be an independent risk factor for blood clots that in some cases may benefit from preventive treatment. 看不太懂，等待楼下的回答。 本人己认领该文献编译，48小时如仍未提交，请其他战友自由认领。 Qinghua HE (WIPM, CAS)由www.nsfc.文件类型:PDF/Adobe Acrobat- 文字版风险共担、成果共享的原则基础上,重点加强 在信息科学、生命科学、农业、材料科学、... H0103 呼吸调控异常 H0104 呼吸系统炎症与感染 H0105 呼吸系统免疫性疾病及变应...www.sciencenet.cn/...88342.pdf-2011-02-04-中医针灸推拿培训学校|中医针灸推拿培训学校7个饮食误区 酒精与癌症的风险 人体穴位图 针灸减肥弊端 人体全息图和反射图 针灸减... 15 - 医学资料医学资料电话 1500 6565 675 丁香园—医药生命科学专业网站 丁香园网...b2b.mainone.com/...1480304.htm-2010-08-16-快照-《世界优秀专家人才名典》网络版在他的带领下、在国家没有增加一分钱投资的情况下.经过近10年的努力,使一个濒临破产... 书刊(侧重科普作品、签名本和创刊号);兼集硬币、纪念章、火花、门券.地图、科学仪具...www.8999.net/...62&SortOrder=1-2010-10-14-快照-[标签:content2]
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作者:admin@医学,生命科学 2011-02-24 00:46
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