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【文摘发布】儿童期体重指数与成年期冠心病危

N Engl J Med. 2007 Dec 6;357(23):2329-37.
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Childhood body-mass index and the risk of coronary heart disease in adulthood.
Baker JL, Olsen LW, Sørensen TI.

Institute of Preventive Medicine, Center for Health and Society, Copenhagen, Denmark. jba@ipm.regionh.dk

BACKGROUND: The worldwide epidemic of childhood obesity is progressing at an alarming rate. Risk factors for coronary heart disease (CHD) are already identifiable in overweight children. The severity of the long-term effects of excess childhood weight on CHD, however, remains unknown. METHODS: We investigated the association between body-mass index (BMI) in childhood (7 through 13 years of age) and CHD in adulthood (25 years of age or older), with and without adjustment for birth weight. The subjects were a cohort of 276,835 Danish schoolchildren for whom measurements of height and weight were available. CHD events were ascertained by linkage to national registers. Cox regression analyses were performed. RESULTS: In 5,063,622 person-years of follow-up, 10,235 men and 4318 women for whom childhood BMI data were available received a diagnosis of CHD or died of CHD as adults. The risk of any CHD event, a nonfatal event, and a fatal event among adults was positively associated with BMI at 7 to 13 years of age for boys and 10 to 13 years of age for girls. The associations were linear for each age, and the risk increased across the entire BMI distribution. Furthermore, the risk increased as the age of the child increased. Adjustment for birth weight strengthened the results. CONCLUSIONS: Higher BMI during childhood is associated with an increased risk of CHD in adulthood. The associations are stronger in boys than in girls and increase with the age of the child in both sexes. Our findings suggest that as children are becoming heavier worldwide, greater numbers of them are at risk of having CHD in adulthood. Copyright 2007 Massachusetts Medical Society.

PMID: 18057335 [PubMed - in process]

全文链接:
http://content.nejm.org/cgi/content/full/357/23/2329 Childhood Body-Mass Index and the Risk of Coronary Heart Disease in Adulthood
儿童期体重指数与成年期冠心病危险

Background The worldwide epidemic of childhood obesity is progressing at an alarming rate. Risk factors for coronary heart disease (CHD) are already identifiable in overweight children. The severity of the long-term effects of excess childhood weight on CHD, however, remains unknown.
背景:世界范围的儿童肥胖流行以惊人的速度增长。冠心病的危险因素已经出现在超重的儿童中。但儿童期超重对冠心病长期作用的严重性尚不清楚。
Methods We investigated the association between body-mass index (BMI) in childhood (7 through 13 years of age) and CHD in adulthood (25 years of age or older), with and without adjustment for birth weight. The subjects were a cohort of 276,835 Danish schoolchildren for whom measurements of height and weight were available. CHD events were ascertained by linkage to national registers. Cox regression analyses were performed.
方法:我们调查了儿童期(7-13岁)体重指数与成年后(25岁以后)冠心病之间的关系,校正或不校正出生时体重。研究对象为接受过身高和体重测量的276,835名丹麦学龄儿童组成的队列人群。 通过与国家登记部门联系确认冠心病事件。数据采用回归分析处理。
Results In 5,063,622 person-years of follow-up, 10,235 men and 4318 women for whom childhood BMI data were available received a diagnosis of CHD or died of CHD as adults. The risk of any CHD event, a nonfatal event, and a fatal event among adults was positively associated with BMI at 7 to 13 years of age for boys and 10 to 13 years of age for girls. The associations were linear for each age, and the risk increased across the entire BMI distribution. Furthermore, the risk increased as the age of the child increased. Adjustment for birth weight strengthened the results.
结果:在5,063,622人年的随访中,有儿童期体重指数数据的10,235名男孩和4318名女孩在成年之后被诊断为冠心病或因冠心病而死亡。成年期的冠心病事件的危险,致死性冠心病事件和非致死性冠心病事件,与男孩7-13岁的体重指数和女孩10-13岁的体重指数成正相关。在各年龄段中成线性相关,危险程度在整个体重指数分布范围内逐渐增加。而且,危险程度随着儿童的年龄增加而增加。在校正出生体重后这一关系进一步加强。
Conclusions Higher BMI during childhood is associated with an increased risk of CHD in adulthood. The associations are stronger in boys than in girls and increase with the age of the child in both sexes. Our findings suggest that as children are becoming heavier worldwide, greater numbers of them are at risk of having CHD in adulthood.
结论:儿童期的高体重指数与成年期的冠心病危险相关。这一关系在男孩中更强,而且在两个性别中均随年龄增加而增加。我们的研究提示随着世界范围的儿童体重的增加,更多的人在成年后处于罹患冠心病的危险中。 编译(471字)

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作者:admin@医学,生命科学    2011-02-24 17:11
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