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【medical-news】左氧氟沙星对儿童中耳炎有效
NEW YORK (Reuters Health) Jan 10 - The fluoroquinolone levofloxacin is highly effective against bacterial pathogens associated with acute otitis media in children, according to researchers.
In the December issue of the Pediatric Infectious Disease Journal, Dr. Adriano Arguedas of Instituto de Atencion Pediatrica, San Jose, Costa Rica and colleagues, note that levofloxacin has an excellent record in dealing with respiratory pathogens.
To determine its efficacy and safety in acute otitis media, the researchers studied 205 children with, or at high risk for persistent or recurrent disease. They ranged in age from 6 months to 4 years.
In this open-label study, the children underwent tympanocentesis before and 3 to 5 days after receiving levofloxacin 10 mg/kg twice daily. Levofloxacin treatment was continued for 10 days.
Pathogens recovered from cultures of middle ear fluid were Streptococcus pneumoniae, S. pyogenes, Haemophilus influenzae and Moraxella catarrhalis. All isolates were susceptible to levofloxacin.
Bacteria were eradicated from the middle ear fluid of 88% of evaluable children during treatment, including 31 of 37 of those infected with S. pneumoniae and all 54 who had H. influenzae infection.
The clinical success rate was 92% in bacteriologically evaluable children and 94% overall.
Treatment limiting side effects were seen in only 6% of the children. The most common was vomiting, which affected 4% of the participants. The researchers call for larger comparative trials, but, in light of these findings conclude that levofloxacin is safe and effective in treatment of acute otitis media in such patients.
Pediatr Infect Dis 2006;25:1102-1109.
http://www.medscape.com/viewarticle/550595 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Levofloxacin Effective for Middle Ear Infection in Children
左氧氟沙星对儿童中耳炎有效
NEW YORK (Reuters Health) Jan 10 - The fluoroquinolone levofloxacin is highly effective against bacterial pathogens associated with acute otitis media in children, according to researchers.
纽约（路透社健康栏目）1月10日，研究表明左氧氟沙星对儿童急性中耳炎相关的细菌性病原体效果显著。
In the December issue of the Pediatric Infectious Disease Journal, Dr. Adriano Arguedas of Instituto de Atencion Pediatrica, San Jose, Costa Rica and colleagues, note that levofloxacin has an excellent record in dealing with respiratory pathogens.
《儿科传染病杂志》12月刊，Costa Rica圣何塞儿科学院的Adriano Arguedas医师及其同事表示，左氧氟沙星抗呼吸道病原体有效果良好记载。
To determine its efficacy and safety in acute otitis media, the researchers studied 205 children with, or at high risk for persistent or recurrent disease. They ranged in age from 6 months to 4 years.
为了确定左氧氟沙星对急性中耳炎的疗效和安全性，研究者研究了205名患有顽固性或再发的急性中耳炎高危性的儿童。将他们按年龄从6个月到4年分组。
In this open-label study, the children underwent tympanocentesis before and 3 to 5 days after receiving levofloxacin 10 mg/kg twice daily. Levofloxacin treatment was continued for 10 days.选取曾做过鼓膜穿刺术，使用左氧氟沙星10 mg/kg每日两次3到5日后的儿童做开放性研究，使用左氧氟沙星继续治疗10天。
Pathogens recovered from cultures of middle ear fluid were Streptococcus pneumoniae,
S. pyogenes, Haemophilus influenzae and Moraxella catarrhalis. All isolates were susceptible to levofloxacin.
取中耳液做病原学培养的病原体是化脓性肺炎链球菌，流感嗜血杆菌和粘膜炎莫拉菌，并都对左氧氟沙星敏感。
Bacteria were eradicated from the middle ear fluid of 88% of evaluable children during treatment, including 31 of 37 of those infected with S. pneumoniae and all 54 who had H. influenzae infection.
细菌取自88%的符合研究条件的儿童治疗期间的中耳液，包括37例被感染S. pneumoniae得31例和所有被感染 H. influenzae的54例。
The clinical success rate was 92% in bacteriologically evaluable children and 94% overall.
细菌学评价的儿童临床治愈率是92%，整体评价临床治愈率是94%。
Treatment limiting side effects were seen in only 6% of the children. The most common was vomiting, which affected 4% of the participants. The researchers call for larger comparative trials, but, in light of these findings conclude that levofloxacin is safe and effective in treatment of acute otitis media in such patients.
只有参与研究儿童的6%在治疗中出现有限的副作用，最常见的是呕吐，占参与者的4%。研究者做了大量对照实验，根据这些研究表明，左氧氟沙星治疗儿童急性中耳炎安全有效。
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作者:admin@医学,生命科学 2011-05-27 05:14
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