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（Science News －－编译 ）男性的避孕可能性scien
29 march 2005
男性的避孕可能性
Newcastle大学的Hunter医学研究学会 (HMRI)的研究人员正在进行可反复使用男性避孕药物作为他们研究男性避孕的课题。
Newcastle大学科学和信息技术系的Mark Baker医生已经确定包括扮演男性不孕主要的角色的一些激酶在内的关键酶。
这个发现引导研究人员在可反复使用男性避孕药物研究上取得进展，药物能抑制精子的关键酶，从而导致不孕。药效过后激酶的功能恢复正常,这是一种可反复使用的，安全的避孕方法。
研究工作使用由GE医疗开发的空间凝胶剂技术(2D萤光差别凝胶电泳)能很快地比较正常的和避孕的精子样本的蛋白质剖面结构的差别。
Baker医生说,"使用这项技术使我们能有效地绘制每个样本图。 通过复盖，我们能识别哪一种蛋白质是正常的和避孕的样本共有的，哪一种蛋白质是缺失的。 其中一种蛋白质被识别为能最终导致男性避孕的蛋白激酶。"
" 我们然后开始观察缺失的蛋白质去追踪导致差别的原因 ", Baker医生说。 " 有1/10的澳洲男性不孕而且比率还在上升, 现阶段我们还不知道原因".
Baker医生说说," 我们相信，这项研究是有前途的，几年后它将在男性的避孕和治疗男性不育方面发挥作用。"。
Newcastle大学的优生优育中心是世界上积极地研究男性不育的八所机构之一。
原文：
http://www.sciencedaily.com/releases/2005/03/050328182717.htm
29 march 2005
Male Contraception Possibility
Hunter Medical Research Institute (HMRI) researchers at the University of Newcastle are working on a reversible male contraceptive as part of their studies into male infertility.
Dr Mark Baker from the University's Faculty of Science and Information Technology has identified key enzymes including certain kinases that are believed to play a major role in male infertility.
The discovery has led researchers toward the development of a reversible male contraceptive, which would work by inhibiting the key enzymes in sperm, thereby causing infertility. Removal of the drug would allow the function of the kinase to resume as per normal, allowing a reversible, safe method of contraception.
The work uses two dimensional gel technology DIGE (2-D Fluorescence Difference Gel Electrophoresis) developed by partner GE Healthcare which allows the researchers to quickly compare the difference in protein profiles of multiple normal and infertile sperm samples.
Dr Baker says, "By using the DIGE technology we can effectively create a map of each sample and by overlaying them we can identify which proteins are shared by the normal and infertile samples and which proteins are missing in each. One of the proteins identified a protein kinase which may ultimately lead to a male contraception."
"We then start looking at those missing proteins to track down the causes for the differences," said Dr Baker. "Up to ten per cent of the Australian male population is infertile and the rate is rising, at this stage we just don't know why."
Dr Baker says, "While this research is promising we believe it will still take several years before a male contraceptive using this technology or a treatment for infertility will be available."
The University of Newcastle's Centre of Excellence in Biotechnology and Development is one of only eight in the world actively researching male infertility
xiaowenok edited on 2005-03-30 14：13 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-04-15 17:14
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