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【drug-news】检测药物不良反应有新招
WASHINGTON (Reuters) - A new panel of tests aimed at finding out how drugs may damage cells has turned up a series of interactions that may explain some of the serious side-effects of statin drugs, researchers said on Sunday.
Statins, the wildly popular cholesterol-lowering drugs, may interact with at least one blood pressure drug to damage the mitochondria, the powerhouses of cells, the researchers reported in the journal Nature Biotechnology.
Their study also may lead to the development of drugs to treat diabetes and diseases of aging and better ways to screen for drug side-effects, the researchers said.
Vamsi Mootha of the Broad Institute at Harvard University and the Massachusetts Institute of Technology said they had made their new database freely available to other scientists to use for screening drugs.
The mitochondria are structures in cells that make adenosine triphosphate, or ATP, which helps power cells. Mootha's team tested more than 2,000 drugs on cells to see how they might interfere with this process.
Their test looks at gene function, ATP levels and other measures of how well the mitochondria are working.
Many patients who take statins have reported side-effects that include muscle pain and weakness. The cause is not well understood but Mootha has long suspected the mitochondria are involved. The effects have been hard to pin down because studies of different groups have produced conflicting results.
Mootha's team said their findings showed some statins lower ATP levels and interfere with the mitochondria.
Fluvastatin is sold by Novartis under the brand name Lescol, lovastatin is sold under the brand name Mevacor and simvaststin is sold as Zocor.
PATTERN OF DYSFUNCTION
Three others -- atorvastatin, made by Pfizer under the brand name Lipitor, pravastatin or Pravachol, made by Bristol Myers Squibb and rosuvastatin, sold under the Crestor brand name by AstraZeneca -- had little effect, they said.
"We asked what pattern of dysfunction they cause in the mitochondria," Mootha said in a telephone interview. "Once we figured out what the pattern was we asked what other FDA-approved drugs give rise to that same pattern of mitochondrial dysfunction."
They found a few.
"We were struck by the fact that one of these nearest-neighbor drugs is propranolol, a widely used antihypertensive agent," they wrote.
Propranolol is a so-called beta blocker drug sold by Wyeth under the brand name Inderal and also available generically.
"That was a bit of a surprise," Mootha said. "And it is important because so many patients are on a statin as well as blood pressure medication."
Other drugs that resembled statins in their activity in mitochondria included amoxapine, cyclobenzaprine, griseofulvin, pentamidine, paclitaxel, propafenone, ethaverine, trimeprazine and amitriptyline.
A similar process may be going on in diabetes, nerve degeneration and aging, Mootha's team said. They found a number of drugs, including the cancer drug vinblastine may counter this process.
Mootha cautioned that his group has worked only in batches of muscle cells grown in the lab so far and that far more tests are needed.
http://www.reuters.com/article/healthNews/idUSN247722520080224 我自己认领吧 New test shows source of disease side-effects
筛查药物不良反应有新招
WASHINGTON (Reuters) - A new panel of tests aimed at finding out how drugs may damage cells has turned up a series of interactions that may explain some of the serious side-effects of statin drugs, researchers said on Sunday.
华盛顿（路透社）报道，一系列本来旨在研究药物损伤细胞的机制的实验，后来却意外发现了他汀类导致一些严重不良反应的原因。
Statins, the wildly popular cholesterol-lowering drugs, may interact with at least one blood pressure drug to damage the mitochondria, the powerhouses of cells, the researchers reported in the journal Nature Biotechnology.
《Nature Biotechnology》报道，他汀类作为一种广泛应用的降脂药，会和至少一种降压药互相作用进而损害细胞的能量来源线粒体。
Their study also may lead to the development of drugs to treat diabetes and diseases of aging and better ways to screen for drug side-effects, the researchers said.
这项研究还可能引导开发治疗糖尿病和一些退化性疾病的药物，也会指导筛查药物的不良反应。
Vamsi Mootha of the Broad Institute at Harvard University and the Massachusetts Institute of Technology said they had made their new database freely available to other scientists to use for screening drugs.
来自哈佛和麻省的研究者说，他们已经将该研究的数据公开，让其他的研究者都可以利用该方法进行药物筛查。
The mitochondria are structures in cells that make adenosine triphosphate, or ATP, which helps power cells. Mootha's team tested more than 2,000 drugs on cells to see how they might interfere with this process.
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作者:admin@医学,生命科学 2011-04-09 05:14
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