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【Fertility & Sterility】生殖系统器官移植：进展与
Objective
To review the advances and controversies in the field of reproductive organ transplantation.
Result
Although many cancer treatments can damage female reproductive organs, leading to temporary or permanent infertility, recent advances in cancer management have translated into improved patient survival, making preservation of reproductive function a more important priority than ever before. Reproductive organ transplantation represents a new potential treatment for patients facing infertility as a result of cancer treatment. Pregnancies have now been reported from several centers after transplanting fresh and frozen ovarian tissue pieces. The longevity of the graft and its potential long-term complications are unknown. However, it seems clear that the ovarian tissue graft has a shortened life span. Allogeneic reproductive organ transplants are under investigation. Patients must take immunosuppressive medications following heterologus transplantation, and these medications can cause adverse side effects. The effects on the fetus are largely unknown.
Conclusion
Despite the recent biologic and clinical advances, reproductive organ transplantation remains experimental and controversial.
Key Words: Ovarian transplantation; immunosuppression; cryopreservation; uterine transplantatio
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关注，迟了点。。 Reproductive organ transplantation: advances and controversies
生殖器官的移植：进展和争议
Objective
目的
To review the advances and controversies in the field of reproductive organ transplantation.
回顾生殖器官移植领域的进展和争议。
Result
结果
Although many cancer treatments can damage female reproductive organs, leading to temporary or permanent infertility, recent advances in cancer management have translated into improved patient survival, making preservation of reproductive function a more important priority than ever before. Reproductive organ transplantation represents a new potential treatment for patients facing infertility as a result of cancer treatment. Pregnancies have now been reported from several centers after transplanting fresh and frozen ovarian tissue pieces. The longevity of the graft and its potential long-term complications are unknown. However, it seems clear that the ovarian tissue graft has a shortened life span. Allogeneic reproductive organ transplants are under investigation. Patients must take immunosuppressive medications following heterologus transplantation, and these medications can cause adverse side effects. The effects on the fetus are largely unknown.
尽管一些肿瘤治疗能够摧毁女性生殖器官，导致暂时性或永久性不育，但是最近在肿瘤治疗上的进展已经转移至提高病人的生存率，从而使保护病人的生殖功能变成比以前更为优先考虑的事情。生殖器官移植为那些因肿瘤治疗而导致面临不育的病人提供了一个新的潜在的治疗方案。有几个中心已经报告，在接受了新鲜冰冻的卵巢标本后，病人出现妊娠。移植物的寿命和其潜在的长期并发症尚无人可知。然而，有一点似乎很清楚，就是卵巢组织的移植物的生存期不长。同种异体生殖器官移植仍在研究中。在异体移植后，病人必须服用免疫抑制药物，这些药物能够导致不利的副作用。对胎儿的影响基本上一无所知。
Conclusion
结论
Despite the recent biologic and clinical advances, reproductive organ transplantation remains experimental and controversial.
尽管最近的生物学和临床出现了进展，生殖器官移植仍旧处于试验阶段并存在争议。
Key Words: Ovarian transplantation; immunosuppression; cryopreservation;
uterine transplantation
关键词：卵巢移植、免疫抑制、冷冻保存、子宫移植
编译如下：
生殖器官的移植：进展和争议
目的
回顾生殖器官移植领域的进展和争议。
结果
尽管一些肿瘤治疗能够摧毁女性生殖器官，导致暂时性或永久性不育，但是最近在肿瘤治疗上的进展已经转移至提高病人的生存率，从而使保护病人的生殖功能变成比以前更为优先考虑的事情。生殖器官移植为那些因肿瘤治疗而导致面临不育的病人提供了一个新的潜在的治疗方案。有几个中心已经报告，在接受了新鲜冰冻的卵巢标本后，病人出现妊娠。移植物的寿命和其潜在的长期并发症尚无人可知。然而，有一点似乎很清楚，就是卵巢组织的移植物的生存期不长。同种异体生殖器官移植仍在研究中。在异体移植后，病人必须服用免疫抑制药物，这些药物能够导致不利的副作用。对胎儿的影响基本上一无所知。
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作者:admin@医学,生命科学 2011-04-07 17:16
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