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【文摘发布】急性HCV感染CD4 T细胞与CD8 T细胞作用
Author: Kaplan DE, Sugimoto K, Newton K, Valiga ME, Ikeda F, Aytaman A, Nunes FA, Lucey MR, Vance BA, Vonderheide RH, Reddy KR, McKeating JA, Chang KM.
Resourse: Gastroenterology. 2007 Feb;132(2):654-66. Epub 2006 Nov 29.
BACKGROUND & AIMS: Acute hepatitis C virus (HCV) infection becomes chronic in the majority of patients. Although HCV-specific CD4 T-cell response is associated with HCV clearance, less is known about virus-specific CD8 T-cell or neutralizing antibody (nAb) responses and the role of CD4 help in their induction during acute infection. METHODS: HCV-specific CD4, CD8, and HCV pseudoparticle (HCVpp) nAb responses were monitored in acutely HCV-infected patients to define their relative contributions to viral clearance. RESULTS: Our results show that the outcome of acute hepatitis C is associated with a functional hierarchy in HCV-specific CD4 T-cell response and the scope of virus-specific, total T-cell interferon-gamma response. HCV-specific CD8 T-cell response was readily detectable in acutely HCV-infected patients regardless of virologic outcome or virus-specific CD4 T-cell response. In contrast, HCVpp-specific nAbs were readily detected in patients with chronic evolution and impaired virus-specific CD4 T-cell response but not in patients who cleared infection with robust virus-specific CD4 T-cell response. CONCLUSIONS: The outcome of acute hepatitis C is associated with efficient virus-specific CD4 T-cell response without which HCV-specific CD8 T-cell and heterologous nAb responses may develop but fail to clear viremia. Furthermore, HCV-specific nAb responses may not be induced despite robust virus-specific CD4 T-cell response.
PMID: 17258733 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 。 Title: Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C
标题：急性HCV感染CD4 T细胞与CD8 T细胞作用并不协调
Author: Kaplan DE, Sugimoto K, Newton K, Valiga ME, Ikeda F, Aytaman A, Nunes FA, Lucey MR, Vance BA, Vonderheide RH, Reddy KR, McKeating JA, Chang KM.
作者：Kaplan DE，Sugimoto K，Newton K，Valiga ME，Ikeda F，Aytaman A，Nunes FA，Lucey MR，Vance BA，Vonderheide RH，Reddy KR，McKeating JA，Chang KM。
Resourse: Gastroenterology. 2007 Feb;132(2):654-66. Epub 2006 Nov 29.
来源：《肠胃病学》；2007年2月；132(2)：654-66。电子出版物2006 11月29。
BACKGROUND & AIMS: Acute hepatitis C virus (HCV) infection becomes chronic in the majority of patients. Although HCV-specific CD4 T-cell response is associated with HCV clearance, less is known about virus-specific CD8 T-cell or neutralizing antibody (nAb) responses and the role of CD4 help in their induction during acute infection.
背景与目标：丙型肝炎病毒(HCV)急性感染的病人大多数转成了慢性。虽然HCV特异性CD4 T细胞反应与HCV清除有关，但对病毒特异性CD8 T细胞或中和抗体（nAb）反应及急性感染期间CD4在帮助诱导中扮演的角色知之甚少。
METHODS: HCV-specific CD4, CD8, and HCV pseudoparticle (HCVpp) nAb responses were monitored in acutely HCV-infected patients to define their relative contributions to viral clearance.
方法：监测HCV急性感染患者体内HCV特异性CD4、CD8和HCV 伪粒子(hcvpp)中和抗体反应以确定其对病毒清除的相对贡献。
RESULTS: Our results show that the outcome of acute hepatitis C is associated with a functional hierarchy in HCV-specific CD4 T-cell response and the scope of virus-specific, total T-cell interferon-gamma response. HCV-specific CD8 T-cell response was readily detectable in acutely HCV-infected patients regardless of virologic outcome or virus-specific CD4 T-cell response. In contrast, HCVpp-specific nAbs were readily detected in patients with chronic evolution and impaired virus-specific CD4 T-cell response but not in patients who cleared infection with robust virus-specific CD4 T-cell response.
结果：我们的结果表明丙型肝炎急性感染的后果与HCV特异性、病毒特异性程度及总T细胞干扰素γ反应的功能层次有关。无论病毒学结果和HCV特异性CD4T细胞反应结果如何，HCV特异性CD8T细胞反应在急性肝炎感染患者体内均可以轻易检测到。相比之下, HCV 伪粒子(hcvpp)特异性中和抗体（nAb）在那些有慢性进展性和损害性病毒特异性CD4T细胞反应的患者体内可以轻易检测到，而在携有顽固性病毒特异性CD4T细胞反应但已清除体内感染的患者体内则无法检测到。
CONCLUSIONS: The outcome of acute hepatitis C is associated with efficient virus-specific CD4 T-cell response without which HCV-specific CD8 T-cell and heterologous nAb responses may develop but fail to clear viremia. Furthermore, HCV-specific nAb responses may not be induced despite robust virus-specific CD4 T-cell response.
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作者:admin@医学,生命科学 2011-04-07 05:11
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