主页 > 生命科学 >
【medical-news】吸烟减弱了阿司匹林的抗凝效应
Reuters Health
Monday, October 2, 2006
By David Douglas
NEW YORK (Reuters Health) - By increasing the activity of platelets, blood cells that help clot the blood, smoking may weaken the anti-clotting effect of aspirin, new research suggests.
A small daily dose of aspirin is usually recommended for patients who have had a heart attack or stroke to prevent platelets from building up and blocking critical blood vessels.
"Aspirin and other antiplatelet treatments are central to the prevention of heart attack and stroke," Dr. Michael Domanski told Reuters Health. "A clearer understanding of how to best predict the level of protection provided in a specific individual is a research question of potentially great public health importance."
As they report in the American Journal of Cardiology, Domanski of the National Heart, Lung and Blood Institute in Bethesda, Maryland and colleagues conducted a study to determine which factors predict a poor anti-clotting response to aspirin.
About one third of the 123 patients in the study were smokers. Their ages ranged from 21 to 95 years. About half of the subjects were women and most had high blood pressure, as well as heart disease.
Sixty-six patients were taking low-dose aspirin at 81 milligrams per day, and tests showed that eight of them did not respond to the drug. When the dose was increased to 325 mg per day, only one remained resistant.
In the other 57 patients, who were taking 325 mg of aspirin per day, three were resistant. When they were given a dose of clopidogrel (Plavix), another anti-platelet drug, and tested 4 hours later, two had become responders.
In the final analysis, smokers were nearly 12-times more likely to be resistant to aspirin than were non-smokers. Thus, the researchers conclude, the finding "adds still more weight to the importance of abstinence from smoking."
SOURCE: American Journal of Cardiology, September 2006. 认领：） Smoking weakens anti-clotting effect of aspirin
吸烟减弱了阿司匹林的抗凝效应
Reuters Health
路透社健康版
Monday, October 2, 2006
2006年10月2日，星期一
By David Douglas
大卫道格拉斯
NEW YORK (Reuters Health) - By increasing the activity of platelets, blood cells that help clot the blood, smoking may weaken the anti-clotting effect of aspirin, new research suggests.
纽约（路透社健康版）- 新的研究发现，血细胞能通过增强血小板的活性有助于凝血，而吸烟可能会减弱阿司匹林的抗凝作用。
A small daily dose of aspirin is usually recommended for patients who have had a heart attack or stroke to prevent platelets from building up and blocking critical blood vessels.
通常推荐患有心脏病发作或者中风的患者每日服用小剂量的阿司匹林抑制血小板聚集堵塞血管。
"Aspirin and other antiplatelet treatments are central to the prevention of heart attack and stroke," Dr. Michael Domanski told Reuters Health. "A clearer understanding of how to best predict the level of protection provided in a specific individual is a research question of potentially great public health importance."
Michael Domanski 博士接受路透社健康版采访时说:“阿司匹林及其它抗血小板治疗对预防心脏病发作和中风极其重要。如何更准确地预测这些药物对某个特定个体的作用，对公共卫生事业有潜在的重要意义。”
As they report in the American Journal of Cardiology, Domanski of the National Heart, Lung and Blood Institute in Bethesda, Maryland and colleagues conducted a study to determine which factors predict a poor anti-clotting response to aspirin.
正如他们在《美国心脏病杂志》中报导的，马里兰Bethesda的国家心肺和血液研究所的Domanski博士和他的同事们进行的研究旨在明确哪些因素预示患者对阿司匹林的抗凝作用反应差。
About one third of the 123 patients in the study were smokers. Their ages ranged from 21 to 95 years. About half of the subjects were women and most had high blood pressure, as well as heart disease.
该项研究中123个患者中大约有1/3是吸烟者。年龄从21到95岁。大约一半个体是女性，并且很多患者患有高血压和心脏疾病。
Sixty-six patients were taking low-dose aspirin at 81 milligrams per day, and tests showed that eight of them did not respond to the drug. When the dose was increased to 325 mg per day, only one remained resistant.
66个患者每天服用81mg的低剂量阿司匹林，测试显示其中8个人对药物没有反应。剂量增加至每天325mg，只有一个人仍为抵抗。
In the other 57 patients, who were taking 325 mg of aspirin per day, three were resistant. When they were given a dose of clopidogrel (Plavix), another anti-platelet drug, and tested 4 hours later, two had become responders.
其余57例每天服用阿司匹林325mg的患者中，三例抵抗。加用另外一种抗血小板药物氯吡格雷（波立维），4小时后检测显示两个患者对药物有了反应。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-01-13 17:14
医学,生命科学网