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【medical-news】阳光：让衰老延迟
Women who spend more time in the sun may be biologically younger and age more slowly than the rest of their age group, a study has found.
Researchers from King’s College London have discovered that women who have higher levels of vitamin D, which enters the body through sunshine, certain foods and nutritional supplementation tend to show signs of being “biologically younger” and healthier than others.
Lead researcher Brent Richards said that the study of 2,160 women aged between 18 and 79 showed that sunshine also could have an effect on age-related illnesses, such as heart disease.
Click here to see the study abstract (subscription required for full study)
"These results are exciting because they demonstrate for the first time that people who have higher levels of vitamin D may age more slowly than people with lower levels of vitamin D,” Richards said. “This could help to explain how vitamin D has a proactive effect on many aging related diseases, such as heart disease and cancer.”
But co-author Tim Spector said that people should not think that being out in the sun all the time was healthy.
“Although it might sound absurd, it’s possible that the same sunshine which may increase our risk of skin cancer may also have a healthy effect on the aging process in general,” Spector said.
The results of the higher serum vitamin D concentrations are associated with longer leukocyte telomer length in women. For the study, researchers measured the women’s telomeres, which were a sign of biological aging.
As people age, telomeres become shorter. But the scientists found that women with higher vitamin D levels tend to have longer telomeres.
The study was published in the latest edition of the American Journal of Clinical Nutrition.
http://www.foxnews.com/story/0,2933,309916,00.html
（缩略图，点击图片链接看原图） 我来认领，48小时不能完成翻译，请其他战友自由认领！ Women Who Spend Time in the Sun May Age More Slowly, Study Says
晒太阳能延缓妇女衰老 telomere应该是与细胞寿命正相关的染色体末端部分DNA--端粒，不应该翻译成调聚物？
曾看过端粒方面的报道^_^ telomer 调聚物
telomere 端粒 Women who spend more time in the sun may be biologically younger and age more slowly than the rest of their age group, a study has found
建议译一项研究发现，花更多时间晒太阳的妇女与其年龄组其余不太晒太阳人相比，在生物学上更年轻，衰老的更慢。 多谢以上战友热心指点！！！ 我觉得这几句这样译
But co-author Tim Spector said that people should not think that being out in the sun all the time was healthy.
但是同组的Tim Spector说，人们应该相信长时间的晒太阳并不利于健康 http://www.tudou.com/programs/view/e6v1cePJs6s/ 以前我们知道，长时间暴露在阳光下，会增加得皮肤癌的危险，而且皮肤受到紫外线的伤害和破坏会衰老得更快，这篇文章真让人吃惊，和以往的认识相反，晒太阳又会从整体上减缓人衰老的速度，那么，是晒还是不晒？或者，在防晒的同时增加VD的摄入量会怎样？是否可以两全？ 各种各样的说法都有,任何事情都有双面性,阳光肯定对人体有好处,但肯定也有坏处,看怎么这个度,现在这个说法比较新鲜. 非常遗憾的是，原文只是确认了端粒酶长度与维生素D浓度之间的关系。晒太阳有助于维生素D的浓度的升高，但不是唯一原因。实际上，摘要中连阳光这个字眼都没有提到，我不明白为什么新闻报道非要与阳光拉上关系。
是新闻记者这样做也就算了，象丁香园这样有专业精神的网站跟风，确实难以理解。
Richards JB, Valdes AM, Gardner JP, Paximadas D, Kimura M, Nessa A, Lu X, Surdulescu GL, Swaminathan R, Spector TD, Aviv A. 2007. Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women. Am J Clin Nutr. 2007 Nov;86(5):1420-1425. BACKGROUND: Vitamin D is a potent inhibitor of the proinflammatory response and thereby diminishes turnover of leukocytes. Leukocyte telomere length (LTL) is a predictor of aging-related disease and decreases with each cell cycle and increased inflammation. OBJECTIVE: The objective of the study was to examine whether vitamin D concentrations would attenuate the rate of telomere attrition in leukocytes, such that higher vitamin D concentrations would be associated with longer LTL. DESIGN: Serum vitamin D concentrations were measured in 2160 women aged 18-79 y (mean age: 49.4) from a large population-based cohort of twins. LTL was measured by using the Southern blot method. RESULTS: Age was negatively correlated with LTL (r = -0.40, P < 0.0001). Serum vitamin D concentrations were positively associated with LTL (r = 0.07, P = 0.0010), and this relation persisted after adjustment for age (r = 0.09, P < 0.0001) and other covariates (age, season of vitamin D measurement, menopausal status, use of hormone replacement therapy, and physical activity; P for trend across tertiles = 0.003). The difference in LTL between the highest and lowest tertiles of vitamin D was 107 base pairs (P = 0.0009), which is equivalent to 5.0 y of telomeric aging. This difference was further accentuated by increased concentrations of C-reactive protein, which is a measure of systemic inflammation. CONCLUSION: Our findings suggest that higher vitamin D concentrations, which are easily modifiable through nutritional supplementation, are associated with longer LTL, which underscores the potentially beneficial effects of this hormone on aging and age-related diseases.
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作者:admin@医学,生命科学 2011-02-24 05:14
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