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【medical-news】Proepithelin对膀胱癌扩散起关键作用
纽约（路透社健康新闻）－生长因子proepithelin诱导膀胱癌迁移和侵袭，而癌细胞迁移和侵袭是引起转移的2个关键步骤。这份科学研究发表于《癌症研究》7月份杂志上。
“尽管膀胱癌是最常见的恶性肿瘤之一，但有关决定尿路上皮的恶性转化的分子机制知之甚少。”费城的托马斯 杰斐孙大学的Kimmel癌症中心的Andrea Morrione博士和其同事在文章中指出。
他们指出，大多数膀胱肿瘤起源于膀胱上皮，尽管采用了手术、化疗或免疫治疗，但肿瘤仍常复发和/或转移。
Morrione博士和同事写道：“我们的结果提供了第一手证据，那就是proepithelin在刺激膀胱癌细胞迁移和浸润中发挥作用，同时也支持了这种生长因子在建立浸润表型中起着关键作用的假说。”
Proepithelin，也称为progranulin、acrogranin、PC源性生长因子或granulin-epithelin前体，是细胞生长、迁移和转化的重要调控因子。该生长因子在乳腺癌、卵巢癌、肾癌和胶质母细胞瘤中呈过表达。
Morrione和同事应用纯化的人重组proepithelin研究了proepithelin对移行细胞癌来源的细胞系的作用。
虽然proepithelin不大影响细胞的生长，但它能增强癌细胞的迁移和浸润。根据以前的研究显示，它也能在体外刺激伤口愈合。
这些效应需要MAPK途径和桩蛋白的活化，后者与细胞黏附密切相关。
随着研究继续，proepithelin可逐渐成为膀胱肿瘤诊断和预后的一个有价值的临床标记物。Morrione和同事推断道。它也能够为提高癌症的治疗方法提供新的指导。
Proepithelin Key to Bladder Cancer Spread; Potential Drug Target
NEW YORK (Reuters Health) Jul 26 - The growth factor proepithelin induces migration and invasion of bladder cancer, two key steps leading to metastasis, scientists report in the July 15th issue of Cancer Research.
"Although bladder cancer is one of the most common malignancies, very little is known about the molecular mechanisms that determine malignant transformation in the urothelial lining the bladder wall," Dr. Andrea Morrione and colleagues from the Kimmel Cancer Center, Thomas Jefferson University in Philadelphia point out in the paper.
Most bladder tumors arise in the bladder epithelium, and often recur and/or metastasize, regardless of treatment with surgery, chemotherapy, or immunotherapy, they also note.
"Our results," write Dr. Morrione and colleagues, "provide the first evidence for a role of proepithelin in stimulating migration and invasion of bladder cancer cells, and support the hypothesis that this growth factor may play a critical role in the establishment of the invasive phenotype."
Proepithelin, which is also known as progranulin, acrogranin, PC-derived growth factor, or granulin-epithelin precursor, is an important regulator of cell growth, migration, and transformation. The growth factor is overexpressed in breast, ovarian, and renal cancer as well as in glioblastomas.
Dr. Morrione and colleagues investigated the effects of proepithelin on transitional cell carcinoma-derived cells using purified human recombinant proepithelin.
Although proepithelin did not appreciably affect cell growth, it did enhance motility and invasion of the cells, as mentioned. It also stimulated in vitro wound closure, as has been shown in previous studies.
These effects required the activation of the MAPK pathway and paxillin, a protein associated with cellular attachment.
With continued study, proepithelin may turn out to be a useful clinical marker for diagnosis and prognosis in bladder tumors, conclude Dr. Morrione and colleagues. It could also provide new leads for improved therapeutic approaches against this cancer. [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-02-07 05:14
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