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【科普】氢气对慢性肾脏病（CKD）的治疗作用
氢气选择性抗氧化发现以来，已经在各种各样炎症和氧化损伤类疾病中证明了它的神奇效果，3年来已经发表的论文达到将近70篇，在肾疾病方面，已有2篇关于肾脏缺血再灌注损伤的研究和1篇肾脏移植后肾病的研究。也有几篇关于糖尿病肾脏损伤的临床研究和关于在透析液中溶解氢气的新型透析液的研究。但过去没有关于慢性肾脏病治疗的研究，刚刚收到一篇这方面研究的文章信息，是来自日本的报道，证明给动物饮用含氢水对慢性肾脏病治疗效果的研究。该文章pdf2010年12月30日发表在《肾脏病与透析肾移植杂志》Nephrol. Dial. Transplant。
动物模型制备方法：7周年龄雄性Dahl盐敏感大鼠分成2组，一组17只给不含氢气的水，另一组18只给含氢气的水，所有动物的饮水中盐浓度为0.5%，每天上午和下午换水（2次），水容器为ad libitum材料，通过一个金属管给动物饮用（保持氢气浓度），6周后接扎一侧肾动脉45分钟后再灌注，造成一侧肾脏损害，1周后处死动物（这一周是否仍然给同样的水？）进行组织学和血清学研究。
研究结果发现，对照组血清中炎症因子MCP1、甲基乙二醛(methylglyoxal,MGO)、尿素氮都显著升高（应该是与正常组比较），对侧肾和心脏组织学发现肾小球细胞粘附（glomerular adhesion？）心脏纤维化ED-1 (CD68)和硝基酪氨酸阳性细胞显著增加，治疗组上述变化显著减轻。结果提示，氢气对慢性肾脏病有很好的治疗作用。
Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats
Wan-Jun Zhu1,2, Masaaki Nakayama3,4, Takefumi Mori1,3, Keisuke Nakayama1, Junichiro Katoh1, Yaeko Murata1, Toshinobu Sato1, Shigeru Kabayama2,3 and Sadayoshi Ito1,3
Background. Hydrogen (H2) reportedly produces an antioxidative effect by quenching cytotoxic oxygen radicals. We studied the biological effects of water with dissolved H2 on ischemia-induced cardio-renal injury in a rat model of chronic kidney disease (CKD).
Methods. Dahl salt-sensitive rats (7 weeks old) were allowed ad libitum drinking of filtered water (FW: dissolved H2, 0.00 ± 0.00 mg/L) or water with dissolved H2 produced by electrolysis (EW: dissolved H2, 0.35 ± 0.03 mg/L) for up to 6 weeks on a 0.5% salt diet. The rats then underwent ischemic reperfusion (I/R) of one kidney and were killed a week later for investigation of the contralateral kidney and the heart.
Results. In the rats given FW, unilateral kidney I/R induced significant increases in plasma monocyte chemoattractant protein-1, methylglyoxal and blood urea nitrogen. Histologically, significant increases were found in glomerular adhesion, cardiac fibrosis, number of ED-1 (CD68)-positive cells and nitrotyrosine staining in the contralateral kidney and the heart. In rats given EW, those findings were significantly ameliorated and there were significant histological differences between rats given FW and those given EW.
Conclusion. Consumption of EW by ad libitum drinking has the potential to ameliorate ischemia-induced cardio-renal injury in CKD model rats. This indicates a novel strategy of applying H2 produced by water electrolysis technology for the prevention of CKD cardio-renal syndrome.
本文引用地址： http://www.sciencenet.cn/m/user_content.aspx?id=401118 克拉玛依市科学技术局二八年工作总结文件类型:DOC/Microsoft Word- 文字版将对该技术在临床上的应用和发展起着积极的推动作用. 18、高频电波刀(LEEP)治疗宫... (100块)、《珍爱生命 预防火灾》(50块)、《科学应对突发事件》(60块)、《科技奥运、...kjj.klmy.gov.cn/...局科技工作年报.doc-2010-08-31-科学技术局二八年工作总结" Sheet1文件类型:XLS/Microsoft Excel- 文字版＂相关领域科技工作者,医学院校生命学科学生＂,＂信号转导是一个较新的学科,但发展迅速,... ＂,＂本书独特之处在于:无论基本疾病是什么,其均对慢性肾脏病(CKD)进行了定义和分期,对...www.lrbook.com.cn/...84222.xls-2010-12-13-[标签:content2]
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作者:admin@医学,生命科学 2011-01-05 11:42
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