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【科普】研究显示：抗癫痫药不影响母乳喂养的
Study: Early Results Show Antiepileptic Drugs Do Not Harm Child's Development 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Seizure Drugs OK While Breastfeeding?
母乳喂养时可以服用抗癫痫药物？
Study: Early Results Show Antiepileptic Drugs Do Not Harm Child's Development
研究：早期的研究发现抗癫痫药不影响儿童生长
April 17, 2008 -- Women with epilepsy who wish to breastfeed their children may be able to do so safely without stopping their seizure medications, early results from a landmark study suggest.
2008年4月17日——划时代的早期研究结果表明：患有癫痫病的妇女想母乳喂养他们的孩子可能是安全的而不用停止服用癫痫药。
In animal studies, certain seizure medications can cause cell death in immature brains. Beta-estradiol, the mother's sex hormone, can block this effect while the baby is in the womb, but such protective effects are absent after birth.
在动物实验研究中，治疗癫痫的药物在未成年的大脑中可引起细胞凋亡。当胎儿在母体内，雌性激素—β-雌二醇可阻止这种作用的发生，而当胎儿出生后这种保护作用就不再有了。
"Concern was raised that breastfeeding by women taking antiepilepsy drugs may increase the risk of antiepilepsy drug-induced cell death," study researcher Kimford Meador, MD, with the University of Florida at Gainesville, says in a news release.
“服用抗癫痫药的母乳喂养的妇女的忧虑的增加可能会提升抗癫痫药物引起的细胞死亡的风险，”医学博士kimford meador研究员，在盖恩斯维尔的佛罗里达大学的一个新闻发布会上说。
However, new research presented at the American Academy of Neurology's 60th Anniversary Annual Meeting in Chicago fails to demonstrate that breastfeeding is harmful to a child if the mother is taking certain seizure medications. The study is the first of its kind to examine the effect of breastfeeding and seizure medications.
然而，在美国芝加哥举行的神经学会60周年年会上新的研究未能证实，服用抗癫痫药的妈妈母乳喂养孩子会伤害自己的孩子。这是关于诊断母乳喂养和癫痫药物治疗相互作用的第一次这种方式的研究。
The findings are based on an ongoing study that analyzed the cognitive abilities of 187 children 2 years old whose mothers took one of the following drugs for the treatment of epilepsy: Tegretol, Lamictal, Dilantin, or Depakote.
这一正在进行的研究发现是基于对有认知能力的2岁大的187名儿童的观察的结果，这些孩子的妈妈都服用了卡马西平, 拉莫三嗪,苯妥英, 双丙戊酸钠中的一种抗癫痫药。
Among the study group, 41% of the children were breastfed. The breastfed children scored higher on the Mental Development Index (MDI) test than those who were not breastfed, regardless of the type of seizure medication. However, the difference was not statistically significant when factoring in the mother's IQ.
在研究组中，其中41%的孩子接收母乳喂养。母乳喂养的孩子的精神发育指数（MDI）比非母乳喂养的孩子的更高，不论是服用哪种类型的癫痫药物。然而，妈妈的智商（IQ）的差别在统计学上没有显著差异。
"Our early findings show breastfeeding during antiepilepsy drug treatment doesn't appear to have a negative impact on a child's cognitive abilities," Meador says.
“我们早期的发现表明服用抗癫痫药期间母乳喂养的孩子在认知能力上并没有表现出消极的作用，” Meador博士说。
Researchers caution that more research is needed to confirm their observations. The study analysis is part of the Neurodevelopmental Effects of Antiepileptic Drugs (NEAD) study, an ongoing trial to investigate how the use of seizure medications during pregnancy influences a child's cognitive abilities. Mothers were enrolled during pregnancy. The study aims to re-evaluate each child again at ages 3, 4 1/2, and 6.
研究者警告说需要更多的研究来证实他们的看法。这一研究分析是抗癫痫药对神经发育影响（NEAD）研究的一部分，一个正在进行的研究是在怀孕期间服用癫痫药物如何影响胎儿的认知能力。怀孕期间妈妈都被登记了。研究的目的是每个孩子在3，4 1/2和6岁时重新评估一次。
全文：
母乳喂养时可以服用抗癫痫药物？
研究：早期的研究发现抗癫痫药不影响儿童生长
2008年4月17日——从划时代的早期研究结果表明：患有癫痫病的妇女想母乳喂养他们的孩子可能是安全的而不用停止服用癫痫药。
在动物实验研究中，治疗癫痫的药物在未成年的大脑中可引起细胞凋亡。当胎儿在母体内，雌性激素—β-雌二醇可阻止这种作用的发生，而当胎儿出生后这种保护作用就不再有了。
“服用抗癫痫药的母乳喂养的妇女的忧虑的增加可能会提升抗癫痫药物引起的细胞死亡的风险，”医学博士kimford meador研究员，在盖恩斯维尔的佛罗里达大学的一个新闻发布会上说。
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作者:admin@医学,生命科学 2011-01-18 17:14
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