It offers prospect of quick, non-invasive identification of the dangerous disease
Doctors may some day be able to accurately, rapidly, and non-invasively diagnose lung cancer with nothing more than a quick swab of the mouth, a new study suggests.
Oral cavity tissue damage -- at the molecular level -- appears to be a highly accurate indicator of similar lung tissue damage following long-term exposure to tobacco carcinogens, the researchers said. The prospect of such a novel diagnostic technique raises hope for a faster, easier, and much less painful means to diagnosis lung cancer, they added.
"We tried to figure out whether oral cells mimic or reflect tobacco-induced damage in the lung," said study senior author Dr. Li Mao, a professor of thoracic/head and neck medical oncology, as well as systems biology, at the University of Texas M.D. Anderson Cancer Center in Houston. "And what we found is that more than 90 percent of the time you see the same abnormalities in oral cells that you see in lung tissue."
Texas 大学MD Anderson 癌症研究中心，系统生物学和胸/头颈肿瘤学教授，本研究的高级作者Li Mao博士说：“我们研究是否口腔细胞可类似或反映出烟草引起的肺组织损伤，结果是在超过90%的时间内，你可以发现口腔粘膜细胞与肺组织有相同的异常变化。”
Mao discussed his findings during a Wednesday teleconference at the American Association for Cancer Research annual meeting, in San Diego.
Following Mao's presentation, the results of other studies concerning similar diagnostic advances in other fields of cancer research were presented.
Researchers from Henry Ford Hospital in Detroit said that an analysis of DNA extracted from saliva might ultimately enable physicians to detect early signs of head and neck squamous cell carcinoma -- a disease that currently affects 40,000 Americans.
Scientists from the Dana-Farber Cancer Institute in Boston provided evidence that fallopian tube tissue -- rather than ovarian surface cells -- could be the source for half of all cases of sporadic and hereditary serous carcinoma, the most aggressive form of ovarian cancer. The finding could lead to earlier detection of a disease that currently affects about 200,000 women worldwide.
And a team from the Spanish National Cancer Research Center offered indications that a new way of analyzing antibodies in the blood could lead to a non-invasive way to screen for bladder cancer.
For their lung cancer investigation, Mao and his colleagues examined and compared harmful genetic modifications in a total of 1,774 mouth and lung tissue samples taken from 127 chronic smokers participating in a larger cancer prevention study.
In the sampled DNA, the researchers looked for evidence of a harmful molecular change that short-circuits the function of two genes normally effective at halting tumor growth.
After two analyses conducted over a three-month period, the researchers found that tissue damage of this kind was present almost equally in both mouth and lung tissue. In theory, this makes oral cavity sampling nearly as effective as lung tissue sampling for diagnosing lung cancer.
作者:admin@医学,生命科学 2011-01-14 05:14