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【文摘发布】本期ERJ：接种流感疫苗与死亡率：
Eur Respir J 2007 30: 414-422.
Author:Å. Örtqvist, F. Granath, J. Askling, and J. Hedlund
Abstract:
The 50% reduced overall mortality previously associated with influenza vaccination among the elderly was based on studies neither fully taking into account systematic differences between individuals who accept or decline vaccination nor encompassing the entire general population.
A population-based prospective cohort study was performed in Stockholm County (Sweden), including all persons aged 65 yrs (n = 260,000), over three influenza seasons: 1998/1999, 1999/2000 and 2000/2001. The relative risks of mortality among vaccinated versus unvaccinated individuals were estimated using Cox's proportional hazards regression adjusted for, and stratified by, demographic factors and comorbid conditions during the three seasons and the respective following off-seasons.
Influenza vaccination was associated with an unadjusted reduction in all-cause mortality during the three seasons of 50, 46 and 42%, respectively, which decreased to 14, 19 and 1%, respectively, following adjustment for confounders and differences in mortality between vaccinated and unvaccinated individuals following the influenza season. The numbers needed to treat to prevent one death, during the three seasons, were 297, 158 and 743, respectively.
Vaccination remains the most important measure for prevention of influenza complications in elderly people, although the effectiveness in reducing all-cause mortality in elderly persons is lower than previously thought.
Keywords: Influenza, mortality, vaccination 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 初译后：
Title: Influenza vaccination and mortality: prospective cohort study of the elderly in a large geographical area
题目：流行性感冒疫苗接种和死亡率：广泛地理区域老年人前瞻性队列研究
Eur Respir J 2007 Sep 30: 414-422.
欧洲呼吸病杂志，2007 年9月；30： 414-422
Abstract: 摘要
The 50% reduced overall mortality previously associated with influenza vaccination among the elderly was based on studies neither fully taking into account systematic differences between individuals who accept or decline vaccination nor encompassing the entire general population.
曾有与流感疫苗接种相关的老年人总体死亡率降低50%的报道，该报道基于的研究没有完全考虑到那些接受以及未接受疫苗免疫或者包括了全部普通人群个体间的系统差异。
A population-based prospective cohort study was performed in Stockholm County (Sweden), including all persons aged 65 yrs (n = 260,000), over three influenza seasons: 1998/1999, 1999/2000 and 2000/2001. The relative risks of mortality among vaccinated versus unvaccinated individuals were estimated using Cox's proportional hazards regression adjusted for, and stratified by, demographic factors and comorbid conditions during the three seasons and the respective following off-seasons.
在瑞典的Stochholm地区，进行了一项基于人口的前瞻性队列研究，包括所有年龄65岁的老年人（n=260，000），历时三个流感季节：1998/1999, 1999/2000和2000/2001。使用Cox风险回归模型来对流感疫苗免疫和非免疫组人群死亡率相对风险进行统计学处理，用流行季节和流行季节后低发病率季节的人口统计因素和合并其他疾病等来作为统计校正和分层。
Influenza vaccination was associated with an unadjusted reduction in all-cause mortality during the three seasons of 50, 46 and 42%, respectively, which decreased to 14, 19 and 1%, respectively, following adjustment for confounders and differences in mortality between vaccinated and unvaccinated individuals following the influenza season. The numbers needed to treat to prevent one death, during the three seasons, were 297, 158 and 743, respectively.
在三个流感流行的季节，流感疫苗保护后未经校正的所有病因死亡率降低分别为50、46和42%，流感季节后，接下来应用混杂因素和流感疫苗免疫及未免疫组之间死亡率差异因素校正后，流感疫苗保护后死亡率降低分别为14、19和1%。在这三个流感流行季节，需要治疗以防止病死的数字分别为297、158和743。
Vaccination remains the most important measure for prevention of influenza complications in elderly people, although the effectiveness in reducing all-cause mortality in elderly persons is lower than previously thought.
虽然在减少老年人所有原因死亡率的效度并没有原先预期的高，在老年人流感疫苗免疫仍然是预防流感并发症的最重要措施。
编译后：（共543字）
流行性感冒疫苗接种和全部病因死亡率：广泛地理区域老年人前瞻性队列研究
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作者:admin@医学,生命科学 2011-09-18 17:13
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