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【medical-news】早期的脑部发育与成年伊始的神经
U Of MN Researchers Link Early Brain Development To Adult-onset Neurodegenerative Disease
Researchers at the University of Minnesota's Institute for Human Genetics have shown for the first time that the severity of an adult neurodegenerative disease is tied to how well the brain developed shortly after birth.
The researchers used a mouse model for spinocerebellar ataxia type 1 (SCA 1), a fatal neurodegenerative disease that is associated with the loss of coordination that affects activities such as walking, speaking and swallowing. There is no treatment for this disease, and patients typically die 10-15 years after their first symptoms appear.
"We always suspected that something was going on with the SCA 1 mice developmentally," said Harry Orr, Ph.D., professor of genetics, cell biology and development. "Now, we have the data to support it."
The research will appear in the Nov. 17, 2006 issue of the journal Cell.
Orr and his team manipulated the mouse model for the disease so that the gene that causes SCA 1 could be turned on and off.
In one group of mice, they turned off the gene for approximately two weeks at the beginning of the mice's development; then it was turned back on. In the second group of mice, they left the gene on for the entire time.
After 12 weeks, the researchers observed the mice.
"The difference was dramatic," Orr said.
The mice in the group in which the gene was turned off appeared virtually normal, while the mice in the other group had difficulty standing and walking. Orr said that the discovery suggests that in the future, doctors may be able to target treatment to coincide with critical times in development, lessening the impact of a disease in which symptoms take years to appear.
Although SCA 1 appears later in life, it is possible to do genetic screening at birth to determine if a person is at risk for getting the disease in adulthood.
The researchers next will look into the specific molecular pathways involved in early brain development, Orr said. He added that that in the future, research into the proteins and protein expression may be translated into therapeutic approaches. 本人已认领,若48小时未交译文,请其他战友继续. 明尼苏达大学的人类遗传学研究人员首次揭示出神经退行性病的严重程度,与成人出生后的大脑早期发育状况有关.
研究人员用老鼠1型脊髓小脑(协议书一)模型做实验,这是一种致命的神经退化疾病,它导致共济失调,影响一些活动的进行,如步行、说话及吞咽..--对于这种疾病没有治疗方法,得这种病的典型患者一般在首次出现症状后10到15年去世.
"我们一直怀疑,某些东西一直伴随着1型脊髓小脑鼠发育,"奥尔.亨利这位遗传学、细胞生物学和发展博士、教授说"现在,我们有数据来证明它"
该研究将刊登在2006年11月17日发行的细胞.杂志上
奥尔和他的团队操纵小鼠模型,最终可以调控产生SCA 1的基因使其开启和闭合.
一组小鼠中,在小鼠生长的最初阶段,他们终止了基因调控大约两个星期左右时间,基因调空停止,在另一组里,在整个阶段他们打开基因/
12周后,研究人员观察小鼠
奥尔说,:出现了戏剧性的差异"
关掉基因调空的一组,发育正常.另一组出现异常的站立和行走.奥尔说,这一发现表明,今后,在出现症状早期,医生.可以针对性的治疗,以减轻疾病的影响.
尽管 SCA 1在出生以后发生,可以通过做基因筛选,确定一个人在出生时是否有在成年患病的风险
奥尔说.研究人员下一步将研究有关早期脑发育的分子通路,他补充说,在未来,对蛋白质和蛋白表达的研究可作为研究疫病治疗的方法. [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-02-28 05:11
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