主页 > 医药生命 >
【drug-news】抗癌药物新希望
New cancer drug hope
26 Oct 2006
Scientists helping to develop the next generation of cancer-beating drugs say they have had a major breakthrough with their latest results.
A new class of drugs - being developed by a major pharmaceutical company - targets an enzyme that helps cells divide; in cancer, this enzyme, called Aurora B, goes into overdrive, possibly leading to uncontrolled and abnormal cell divisions.
The University of Manchester team has been studying a chemical that blocks, or inhibits, the catalytic actions of Aurora B and has proven very effective at killing cancer cells in cultures grown in the laboratory.
"The first compounds were designed to inhibit a related enzyme called Aurora A," said Dr Stephen Taylor, who is leading the research in Manchester's Faculty of Life Sciences.
"But our research has shown that inhibiting Aurora B is a far more successful method of killing cancer cells and we have been strongly encouraged by these latest results."
The research - published in the Journal of Cell Science - will be of interest to scientists around the world looking at Aurora inhibitors; there are currently more than 10 companies pursuing Aurora cancer programmes.
"Auroras have attracted worldwide attention but no one has been entirely sure which strategy to follow," said Dr Taylor.
"Our paper clearly demonstrates that targeting Aurora B is a highly attractive avenue to pursue, although inhibition of Aurora A may still have some merits as a potential therapy."
Early clinical trials of the Aurora-B drug's toxicity have also been encouraging, with no major adverse effects to patients being reported. The next stage of trials to test its effectiveness is likely to start shortly.
"A lot of current cancer drugs, while effective, are also toxic; by contrast, the toxic effects of Aurora inhibitors have been relatively mild and so could provide a revolutionary new way to treat cancer in the future."
Aurora A and B are a type of enzyme known as protein kinases; they modify other proteins by chemically adding phosphate groups to them. In cancer, both these protein kinases are 'overexpressed'.
The University of Manchester team has been working on the Aurora B inhibitor in collaboration with pharmaceutical company AstraZeneca. The group published an earlier paper in 2003 that highlighted the potential success of targeting Aurora B. These latest findings further strengthen the team's belief that Aurora B inhibition is the preferred route to an effective cancer therapy.
Ends
Notes for editors:
The first results from the Phase I clinical trials using Aurora inhibitors were presented at the American Society for Clinical Oncology conference in Atlanta in June. More than 30,000 delegates from across the world attended the conference.
For further information contact:
Aeron Haworth
Media Officer
Faculty of Life Sciences
The University of Manchester
Tel: +44 (0)161 275 8383
Mob: +44 (0)7717 881563
Email: aeron.haworth@manchester.ac.uk
Back to menus 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 New cancer drug hope 抗癌药物新希望
26 Oct 2006
Scientists helping to develop the next generation of cancer-beating drugs say they have had a major breakthrough with their latest results.致力于发展抗癌新药物的科学家表示，他们的最近研究结果有重大的突破
A new class of drugs - being developed by a major pharmaceutical company - targets an enzyme that helps cells divide; in cancer, this enzyme, called Aurora B, goes into overdrive, possibly leading to uncontrolled and abnormal cell divisions.这类新药物由一家主要的制药公司研发---靶向作用于促进细胞分裂的酶；在肿瘤中，细胞有丝分裂激酶Aurora B异常表达，它将导致细胞分裂的失控和异常.
The University of Manchester team has been studying a chemical that blocks, or inhibits, the catalytic actions of Aurora B and has proven very effective at killing cancer cells in cultures grown in the laboratory. Manchester大学的研究团体已经研究出了一种能阻碍或者抑制Aurora B作用的化学物质，已经证实这种化学物对杀死实验室培养的肿瘤细胞非常有效。
"The first compounds were designed to inhibit a related enzyme called Aurora A," said Dr Stephen Taylor, who is leading the research in Manchester's Faculty of Life Sciences.“被设计的第一个化合物抑制了一种称之为Aurora A的相关酶，” Manchester大学生命科学系的研究负责人，Stephen Taylor博士表示。
"But our research has shown that inhibiting Aurora B is a far more successful method of killing cancer cells and we have been strongly encouraged by these latest results." “我们的研究表明抑制Aurora B是一种有效得多的杀死癌细胞的方法，最近的研究成果让我们深受鼓舞”。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-02-16 17:12
医学,生命科学网